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  4. Polylactic acid

Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds[1][2].

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Polylactic acid Chemical Structure

Polylactic acid Chemical Structure

CAS No. : 26100-51-6

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Description

Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
26.61 mM
Compound: Lactic acid
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 25299679]
MRC5 IC50
23.93 mM
Compound: Lactic acid
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 25299679]
In Vitro

Polylactic acid (PLA) showed more efficient release of 5-Fluorouracil (HY-90006) than pure polymer in electrospun hybrid nanofibers of 80:20 PLA/PCL ratio (20 g/L glucose). PLA microspheres (10 mg/mL; 35 days) achieved sustained release of Naltrexone (HY-76711) with a cumulative release rate of 67%. 3D-printed PLA/hydroxyapatite scaffolds (2 weeks in vivo) promoted osteoblast proliferation and bone formation in rabbit calvarial defects. PLA-based drug-eluting scaffolds (10 μg /cm2; 30 days) achieved controlled release of paclitaxel and reduced restenosis rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

60000(Average)

Formula

(C3H6O3)x
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)O)O.[x]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 233.33 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation

Purity: ≥98.0%

Data Sheet (268 KB) SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)
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Polylactic acid Related Classifications

Keywords:

Polylactic acid26100-51-6PLABiochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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