Pomalidomide-PEG2-acetic acid (Synonyms: Pomalidomide-PEG2-CH2COOH)

Cat. No.: HY-167759 Purity: 99.43%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Solubility

In Vivo Dissolution Calculator

Help & FAQs

Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is the conjugate composed of a E3 ligase ligand and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis.

For research use only. We do not sell to patients.

Pomalidomide-PEG2-acetic acid Chemical Structure

CAS No. : 2143097-05-4

Size	Price	Stock	Quantity
5 mg	USD 274	In-stock	Estimated Time of Arrival: June 3
10 mg	USD 438	In-stock	Estimated Time of Arrival: June 3
25 mg	USD 875	In-stock	Estimated Time of Arrival: June 3
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is the conjugate composed of a E3 ligase ligand and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis^[1].

Molecular Weight

419.39

Formula

C₁₉H₂₁N₃O₈

CAS No.

2143097-05-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(COCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (238.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3844 mL	11.9221 mL	23.8442 mL
5 mM	0.4769 mL	2.3844 mL	4.7688 mL
10 mM	0.2384 mL	1.1922 mL	2.3844 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Purity: 99.43%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Ma Z, et al., Compounds for modulating syk activity and e3 ubiquitin ligase activity. WO2024102970

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3844 mL	11.9221 mL	23.8442 mL	59.6104 mL
	5 mM	0.4769 mL	2.3844 mL	4.7688 mL	11.9221 mL
	10 mM	0.2384 mL	1.1922 mL	2.3844 mL	5.9610 mL
	15 mM	0.1590 mL	0.7948 mL	1.5896 mL	3.9740 mL
	20 mM	0.1192 mL	0.5961 mL	1.1922 mL	2.9805 mL
	25 mM	0.0954 mL	0.4769 mL	0.9538 mL	2.3844 mL
	30 mM	0.0795 mL	0.3974 mL	0.7948 mL	1.9870 mL
	40 mM	0.0596 mL	0.2981 mL	0.5961 mL	1.4903 mL
	50 mM	0.0477 mL	0.2384 mL	0.4769 mL	1.1922 mL
	60 mM	0.0397 mL	0.1987 mL	0.3974 mL	0.9935 mL
	80 mM	0.0298 mL	0.1490 mL	0.2981 mL	0.7451 mL
	100 mM	0.0238 mL	0.1192 mL	0.2384 mL	0.5961 mL

Pomalidomide-PEG2-acetic acid Related Classifications

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?
1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.
How should solution-form recombinant proteins be stored?
1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that
Why is it necessary to add carrier proteins?
Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.
Carrier protein types and options?
In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

Keywords:

Pomalidomide-PEG2-acetic acid2143097-05-4Pomalidomide-PEG2-CH2COOHE3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Pomalidomide-PEG2-acetic acid (Synonyms: Pomalidomide-PEG2-CH2COOH)

Customer Review

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Pomalidomide-PEG2-acetic acid Related Classifications

Keywords:

Your Recently Viewed Products:

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