2. Apoptosis Epigenetics
  3. Histone Methyltransferase Apoptosis
  4. PRMT5-IN-31

PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min).

For research use only. We do not sell to patients.

PRMT5-IN-31 Chemical Structure

PRMT5-IN-31 Chemical Structure

Size Price Stock Quantity
1 mg USD 380 In-stock
5 mg USD 950 In-stock
10 mg USD 1235 In-stock
25 mg USD 1852 In-stock
50 mg USD 2408 In-stock
100 mg USD 3130 In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

PRMT5-IN-31 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

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Description

PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min)[1].

IC50 & Target

0.31 μM (PRMT5)[1]
Molecular Weight

336.43

Formula

C21H24N2O2
Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@@H](CN1C=CC2=C1C=CC(OC)=C2)CN(C3)CCC4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (148.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9724 mL 14.8619 mL 29.7239 mL
5 mM 0.5945 mL 2.9724 mL 5.9448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9724 mL 14.8619 mL 29.7239 mL 74.3097 mL
5 mM 0.5945 mL 2.9724 mL 5.9448 mL 14.8619 mL
10 mM 0.2972 mL 1.4862 mL 2.9724 mL 7.4310 mL
15 mM 0.1982 mL 0.9908 mL 1.9816 mL 4.9540 mL
20 mM 0.1486 mL 0.7431 mL 1.4862 mL 3.7155 mL
25 mM 0.1189 mL 0.5945 mL 1.1890 mL 2.9724 mL
30 mM 0.0991 mL 0.4954 mL 0.9908 mL 2.4770 mL
40 mM 0.0743 mL 0.3715 mL 0.7431 mL 1.8577 mL
50 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.4862 mL
60 mM 0.0495 mL 0.2477 mL 0.4954 mL 1.2385 mL
80 mM 0.0372 mL 0.1858 mL 0.3715 mL 0.9289 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7431 mL
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PRMT5-IN-31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-31Histone MethyltransferaseApoptosisA549liver microsomecancerantiproliferativecell migrationInhibitorinhibitorinhibit

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