2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite 

Cat. No.: HY-W096141
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Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Structure

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Structure

CAS No. : 1391728-01-0

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Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Related Antibodies

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Description

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Related Antibodies
Molecular Weight

344.39

Formula

C16H29N2O4P
CAS No.
SMILES

N#CCCOP(N(C(C)C)C(C)C)OCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite1391728-01-0PROTAC LinkersInhibitorinhibitorinhibit

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Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
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