PROTAC BET Degrader-12

Cat. No.: HY-158764 Purity: 98.10%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC BET Degrader-12 (Compound 8b) is a PROTAC degrader for bromodomain and extra-terminal domain (BET)-containing proteins, which degrades the BRD3 and BRD4 in a DCAF11-dependent manner. PROTAC BET Degrader-12 inhibits cell viability of KBM7 with a DC₅₀ of 305.2 nM. (Pink: ligand for target protein (+)-JQ-1 (HY-13030); Black: linker (HY-159077); Blue: ligand for E3 ligase (HY-159076))

For research use only. We do not sell to patients.

PROTAC BET Degrader-12 Chemical Structure

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

867.46

Formula

C₄₈H₄₇ClN₈O₄S

Appearance

Solid

Color

White to off-white

SMILES

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCCNC(COC5=CC=C(C=C5)CNC(/C(C#N)=C/C6=CC=C7C=CC=CC7=C6)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (115.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1528 mL	5.7640 mL	11.5279 mL
5 mM	0.2306 mL	1.1528 mL	2.3056 mL
10 mM	0.1153 mL	0.5764 mL	1.1528 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.10%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (245 KB) HNMR (239 KB) RP-HPLC (331 KB) LCMS (161 KB)

Handling Instructions (2659 KB)

References

[1]. Tin G, et al., Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins. Bioorg Med Chem Lett. 2024 Jul 15;107:129779. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1528 mL	5.7640 mL	11.5279 mL	28.8198 mL
	5 mM	0.2306 mL	1.1528 mL	2.3056 mL	5.7640 mL
	10 mM	0.1153 mL	0.5764 mL	1.1528 mL	2.8820 mL
	15 mM	0.0769 mL	0.3843 mL	0.7685 mL	1.9213 mL
	20 mM	0.0576 mL	0.2882 mL	0.5764 mL	1.4410 mL
	25 mM	0.0461 mL	0.2306 mL	0.4611 mL	1.1528 mL
	30 mM	0.0384 mL	0.1921 mL	0.3843 mL	0.9607 mL
	40 mM	0.0288 mL	0.1441 mL	0.2882 mL	0.7205 mL
	50 mM	0.0231 mL	0.1153 mL	0.2306 mL	0.5764 mL
	60 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.4803 mL
	80 mM	0.0144 mL	0.0720 mL	0.1441 mL	0.3602 mL
	100 mM	0.0115 mL	0.0576 mL	0.1153 mL	0.2882 mL