2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C degrader-1

KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: < 100 nM) for cancer research. KRAS G12C degrader-1 is a chaperone-mediated protein degrader (CHAMPs). Pink: KRAS G12C ligand (HY-112493); Blue: HSP90 ligand (HY-170326). Black: linker.

For research use only. We do not sell to patients.

KRAS G12C degrader-1 Chemical Structure

KRAS G12C degrader-1 Chemical Structure

CAS No. : 2768099-51-8

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KRAS G12C degrader-1 Related Antibodies

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Description

KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: < 100 nM) for cancer research. KRAS G12C degrader-1 is a chaperone-mediated protein degrader (CHAMPs). Pink: KRAS G12C ligand (HY-112493); Blue: HSP90 ligand (HY-170326). Black: linker[1].

Molecular Weight

1159.81

Formula

C63H75ClN14O6
CAS No.
SMILES

O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS G12C degrader-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C degrader-12768099-51-8RasInhibitorinhibitorinhibit

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