2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Glutaminase
  4. PROTAC TG2 degrader-2

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study.

For research use only. We do not sell to patients.

PROTAC TG2 degrader-2 Chemical Structure

PROTAC TG2 degrader-2 Chemical Structure

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Based on 1 publication(s) in Google Scholar

PROTAC TG2 degrader-2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].

IC50 & Target

> 100 μM (TG2)
In Vitro

PROTAC TG2 degrader-2 (Compound 7) (10 μΜ, up to 24h) inhibits the migration of OVCAR5 and SKOV3 cell lines in both wound-healing assays and transwell migration assays[1].
PROTAC TG2 degrader-2 (10 μΜ) reduces the adhesion of OVCAR5 and SKOV3 cells to fibronectin[1].
PROTAC TG2 degrader-2 (up to 10 μΜ, 6 h) reduces the level of Transglutaminase 2(TG2) within 6 h in a concentration-dependent manner in both OVCAR5 and SKOV3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC TG2 degrader-2 Related Antibodies

Cell Migration Assay [1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 10 μΜ
Incubation Time: Wound-healing assay: 24 h (OVCAR5 cells) and 12 h (OVCAR5 cells) (SKOV3 cells)
Result: Inhibited the migration.

Western Blot Analysis[1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 0.1, 1 and 10 μΜ (OVCAR5 cells), 1 and 10 μΜ (OVCAR5 cells) (SKOV3 cells)
Incubation Time: 6 h and 24 h
Result: Reduced the level of TG2.
Molecular Weight

876.08

Formula

C47H57N9O6S
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCN(C1=CC(C)=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=N1)C)N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (114.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1414 mL 5.7072 mL 11.4145 mL
5 mM 0.2283 mL 1.1414 mL 2.2829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1414 mL 5.7072 mL 11.4145 mL 28.5362 mL
5 mM 0.2283 mL 1.1414 mL 2.2829 mL 5.7072 mL
10 mM 0.1141 mL 0.5707 mL 1.1414 mL 2.8536 mL
15 mM 0.0761 mL 0.3805 mL 0.7610 mL 1.9024 mL
20 mM 0.0571 mL 0.2854 mL 0.5707 mL 1.4268 mL
25 mM 0.0457 mL 0.2283 mL 0.4566 mL 1.1414 mL
30 mM 0.0380 mL 0.1902 mL 0.3805 mL 0.9512 mL
40 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7134 mL
50 mM 0.0228 mL 0.1141 mL 0.2283 mL 0.5707 mL
60 mM 0.0190 mL 0.0951 mL 0.1902 mL 0.4756 mL
80 mM 0.0143 mL 0.0713 mL 0.1427 mL 0.3567 mL
100 mM 0.0114 mL 0.0571 mL 0.1141 mL 0.2854 mL
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PROTAC TG2 degrader-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TG2 degrader-2PROTACsGlutaminaseOVCAR5SKOV3Ovarian cancerTransglutaminase 2Inhibitorinhibitorinhibit

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