2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. BCA-1/CXCL13

BCA-1/CXCL13

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CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is originally identified in stromal cells in B cell follicles as regulating homing of B cells and subsets of T cells. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. CXCL13 plays a key role in orchestrating cell migration within spatially distinct regions of the secondary lymphoid organs. It strongly attracts B lymphocytes while promoting migration of only small numbers of T cells and macrophages. CXCL13 and its receptor, CXCR5, play fundamental roles in inflammatory, infectious, cancer and immune responses[1][2][3].
CXCL13 exerts its functions through its receptor CXCR5. CXCR5 is highly expressed on mature recirculating B-lymphocytes, a subpopulation of follicular helper T cells (TFH) and skin-derived migratory dendritic cells (DCs), and controls their migration into secondary lymphoid organs towards the gradient of CXCL13. As the loss of the BLR1/CXCR5 receptor is sufficient to disrupt organization of follicles in spleen and Peyer's patches, BCA-1 may act as a B cell homing chemokine. Human BCA-1 competes with radiolabeled IFN-γ inducible protein 10 (IP-10) for binding to the human CXCR3 receptor expressed in Ba/F3 and 293EBNA cell lines. Furthermore, human BCA-1 is an efficacious attractant for human CXCR3 transfected cells. BCA-1 does oes not induce calcium release in B-lymphocytes. In addition, human BCA-1 is an agonist in stimulating GTP gamma S binding. Human BCA-1 is a specific and functional G-protein-linked chemotactic ligand for the human CXCR3 receptor. CXCL13 has been widely implicated in the pathogenesis of a number of autoimmune diseases and inflammatory conditions, as well as in lymphoproliferative disorders. In addition, the CXCL13:CXCR5 axis orchestrates cell-cell interactions that regulate lymphocyte infiltration within the tumor microenvironment[1][2][3].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7131
    BCA-1/CXCL13 Protein, Human

    rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    		Human E. coli
    CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Human is produced in E. coli, and consists of 87 amino acids (V23-P109).
  • HY-P700044AF
    Animal-Free BCA-1/CXCL13 Protein, Human (His)

    BCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    		Human E. coli
    The BCA-1/CXCL13 protein selectively attracts B lymphocytes without affecting T lymphocytes, monocytes, or neutrophils. Unlike other chemokines, it does not induce calcium release from B lymphocytes. Animal-Free BCA-1/CXCL13 Protein, Human (His) is the recombinant human-derived animal-FreeBCA-1/CXCL13 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free BCA-1/CXCL13 Protein, Human (His) is 72 a.a., with molecular weight of ~9.49 kDa.
  • HY-P77911
    BCA-1/CXCL13 Protein, Mouse (HEK293, His)

    ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13

    		Mouse HEK293
    CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Mouse (HEK293, His) is produced in HEK293 cells with a N-Terminal His-tag. It consists of 88 amino acids (I22-A109).
  • HY-P77912
    BCA-1/CXCL13 Protein, Mouse (HEK293, Fc)

    ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13

    		Mouse HEK293
    CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 88 amino acids (I22-A109).
  • HY-P76164
    BCA-1/CXCL13 Protein, Cynomolgus (His)

    C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    		Cynomolgus E. coli
    CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Cynomolgus (His) is produced in E. coli with a N-Terminal His-tag.
  • HY-P700547
    BCA-1/CXCL13 Protein, Rat (His-GST)

    rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    		Rat E. coli
    BCA-1/CXCL13 Protein, a member of the intercrine alpha family, is vital for chemokines involved in intercellular communication and immune responses. As part of this family, BCA-1/CXCL13 likely plays a pivotal role in modulating inflammatory processes and influencing cellular interactions. Further exploration is crucial to unveil specific functions and implications within the broader chemokine CxC family, underscoring its significance in mediating immune responses. BCA-1/CXCL13 Protein, Rat (His-GST) is the recombinant rat-derived BCA-1/CXCL13 protein, expressed by E. coli, with N-GST, N-6*His labeled tag. The total length of BCA-1/CXCL13 Protein, Rat (His-GST) is 86 a.a., with molecular weight of 41 kDa.
  • HY-P700234AF
    Animal-Free CXCL13 Protein, Pig (His)

    C-X-C motif chemokine 13; BCA1; BLC; SCYB13

    		Pig E. coli
    The CXCL13 protein is a member of the intercrine α family and is critical for chemokines involved in intercellular communication and immune responses. In this family, CXCL13 may play a key role in regulating inflammatory processes and influencing cellular interactions. Animal-Free CXCL13 Protein, Pig (His) is the recombinant pig-derived animal-FreeCXCL13 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free CXCL13 Protein, Pig (His) is 88 a.a., with molecular weight of ~10.81 kDa.
Cat. No. Product Name Effect Purity