2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. IGF family
  5. IGFBP-1

IGFBP-1

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The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system that acts as transport proteins, prolongs half-life of IGFs, regulates the clearance of the IGFs, provides a tissue specific localization, and directly modulates IGFs' actions. The IGFBPs comprise a superfamily of six proteins (IGFBP-1-6) that bind to IGFs with high affinity and specificity and a family of IGFBP-related proteins (IGFBP-rPs, since IGFBP-7 to -10), which are structurally similar to the IGFBPs but bind IGFs with much lower affinity. In addition, the effects of IGFBPs on IGFs are regulated in part by IGFBP proteases. Thus, as far as IGF action is concerned, IGFBP proteases may also be regarded as part of the IGF family because they indirectly regulate the action of IGFs

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72608
    IGFBP-1 Protein, Human (HEK293, His)

    Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

    		Human HEK293
    IGFBP-1 protein extends the half-life of IGFs and modulates their activity. It can inhibit or stimulate IGFs' growth-promoting effects, altering their interaction with receptors and fine-tuning signaling pathways. IGFBP-1 promotes cell migration and binds to both IGF1 and IGF2, highlighting its versatile role in modulating IGF signaling pathways. IGFBP-1 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-1 Protein, Human (HEK293, His) is 234 a.a., with molecular weight of 30-35 kDa.
  • HY-P74848
    IGFBP-1 Protein, Rhesus Macaque (HEK293, His)

    Insulin-like growth factor-binding protein 1; IGFBP1

    		Rhesus Macaque HEK293
    IGFBP-1 Protein, a member of the insulin-like growth factor-binding protein (IGFBP) family, extends IGFs' half-life and modulates their growth-promoting effects on cell culture, inhibiting or stimulating these responses. Crucially, it alters the interaction between IGFs and their cell surface receptors and promotes cell migration. Notably versatile, IGFBP-1 shows equal binding affinity for both IGF1 and IGF2, underscoring its diverse role in modulating the biological activities of insulin-like growth factors. IGFBP-1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived IGFBP-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of IGFBP-1 Protein, Rhesus Macaque (HEK293, His) is 234 a.a., with molecular weight of ~30 kDa.
  • HY-P74849
    IGFBP-1 Protein, Canine (HEK293, His)

    Insulin-like growth factor-binding protein 1; PP12; IBP-1;

    		Canine HEK293
    IGFBP-1 Protein is a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factor (IGFs) I and II to extend the half-life of IGFs. IGFBP-1 inhibits proliferation, invasion, migration and apoptosis of HTR-8/SVneo cells by inducing MMP-26 expression. IGFBP1 may be a new prognostic factor and a target of molecular targeted therapy for gastric cancer. IGFBP-1 Protein, Canine (HEK293, His) is the recombinant canine-derived IGFBP-1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P700256
    IGFBP-1 Protein, Mouse (SUMO, His)

    Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

    		Mouse E. coli
    The IGFBP-1 protein is an insulin-like growth factor binding protein that extends the half-life of IGF and modulates its growth-promoting effects in cell cultures, thereby inhibiting or stimulating these responses. Crucially, it alters the interaction between IGF and its cell surface receptors and promotes cell migration. IGFBP-1 Protein, Mouse (SUMO, His) is the recombinant mouse-derived IGFBP-1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of IGFBP-1 Protein, Mouse (SUMO, His) is 247 a.a., with molecular weight of ~43 kDa.
Cat. No. Product Name Effect Purity