1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. PDGFs & PDGFRs Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. PDGFR

Platelet-derived growth factor receptors (PDGFRs) belong to the receptor tyrosine kinase (RTK) family and serve the function of protein tyrosine kinases. PDGFRs are activated by binding to their ligand PDGFs, and involved in a variety of cellular processes, e.g. proliferation, migration, survival, and cancer development. PDGFRs are primarily located in vascular endothelial cells, fibroblasts and Kupffer cells. The two types of receptor, PDGFR-α and PDGFR-β, are structurally similar and consist of extracellular domains with five immunoglobulin (Ig) - like domains and intracellular parts with kinase domains which contain characteristic inserts of about 100 amino acid residues without homology to kinases. Ligand binding occurs mainly to Ig-like domains 2 and 3, and causes dimerization of the receptors, which is further stabilized by direct receptor-receptor interactions involving Ig-like domain 4.The dimerization is a key event in activation since it juxtaposes the intracellular parts promoting autophosphorylation in trans between the receptors. Subsequently, the phosphorylated PDGFR can initiate various downstream signaling events by recruiting SH2 domain-containing molecules such as Src kinase, Grb2, SHP2, PLCγ, Nck, and STAT.

Cat. No. Product Name / Synonyms Species Source
  • HY-P77123
    PDGF R beta Protein, Human (HEK293, C-His-Avi)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
  • HY-P72494
    PDGF R beta Protein, Human (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDGF R beta Protein, Human (HEK293, His) is 499 a.a., with molecular weight of 85-130 kDa.
  • HY-P72495
    PDGF R alpha Protein, Human (HEK293, His)

    Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-2; CD140a; PDGFRA

    Human HEK293
    PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, His) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P73360
    PDGF R beta Protein, Rat (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rat HEK293
    PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74644
    PDGF R beta Protein, Rat (HEK293, Fc)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rat HEK293
    PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P78194
    PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi)

    JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β

    Human HEK293
    PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P77129
    PDGF R beta Protein, Rhesus Macaque (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rhesus Macaque HEK293
    PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Rhesus Macaque (HEK293, His) is 498 a.a., with molecular weight of ~80-96 KDa.
  • HY-P72496
    PDGF R alpha Protein, Mouse (HEK293, His)

    Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-2; CD140a; PDGFRA

    Mouse HEK293
    PDGF R α is a tyrosine-protein kinase receptor with critical effects on embryonic development, cell proliferation, survival, and chemotaxis.Its effects on cell behavior vary depending on the environment and is critical for differentiation of bone marrow mesenchymal stem cells, normal skeletal development, embryonic skull closure, and gastrointestinal mucosal formation.PDGF R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived PDGF R alpha protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P73721
    PDGF R alpha Protein, Rat (HEK293, His)

    Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA

    Rat HEK293
    PDGF R alpha protein is a tyrosine protein kinase receptor for PDGFA, PDGFB, and PDGFC that coordinates embryonic development, cell proliferation, survival, and chemotaxis. Their functions vary, promoting or inhibiting cell proliferation and migration depending on the situation. PDGF R alpha Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R alpha protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P73356
    PDGF R alpha Protein, Human (HEK293, Fc)

    Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA

    Human HEK293
    PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P77127
    PDGF R beta Protein, Human (Biotinylated, HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Human (Biotinylated, HEK293, His) is 499 a.a., with molecular weight of ~57.6 KDa.
  • HY-P77124
    PDGF R beta Protein, Human (HEK293, Fc)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PDGF R beta Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of ~82.8 KDa.
  • HY-P78193
    PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

    PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2

    Human HEK293
    PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is 501 a.a., with molecular weight of 70-83 kDa.
  • HY-P78506
    PDGF R alpha Protein, Human (HEK293, His-Avi)

    PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2

    Human HEK293
    PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, His-Avi) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P73722
    PDGF R alpha Protein, Rat (HEK293, Fc)

    Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA

    Rat HEK293
    PDGF R alpha protein is a tyrosine protein kinase receptor for PDGFA, PDGFB, and PDGFC that coordinates embryonic development, cell proliferation, survival, and chemotaxis. Their functions vary, promoting or inhibiting cell proliferation and migration depending on the situation. PDGF R alpha Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P74645
    PDGF R alpha Protein, Mouse (HEK293, Fc)

    Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA

    Mouse HEK293
    PDGF R α is a tyrosine-protein kinase receptor with critical effects on embryonic development, cell proliferation, survival, and chemotaxis. Its effects on cell behavior vary depending on the environment and is critical for differentiation of bone marrow mesenchymal stem cells, normal skeletal development, embryonic skull closure, and gastrointestinal mucosal formation. PDGF R alpha Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PDGF R alpha protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P77128
    PDGF R beta Protein, Rhesus Macaque (HEK293, Fc)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rhesus Macaque HEK293
    PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P700809
    PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His)

    PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2

    Cynomolgus HEK293
    PDGF R alpha Protein, a tyrosine-protein kinase receptor, crucially influences embryonic development, regulating cell proliferation, survival, and chemotaxis. Its effects on cell behavior vary contextually, either promoting or inhibiting proliferation and migration. Additionally, it plays a significant role in differentiating bone marrow-derived mesenchymal stem cells and is essential for normal skeletal development. PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His) is the recombinant cynomolgus-derived PDGF R alpha protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R alpha Protein, Cynomolgus (501a.a, HEK293, His) is 501 a.a., with molecular weight of 70-85 kDa.
  • HY-P700810
    PDGF R beta Protein, Canine (HEK293, His)

    JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β

    Canine HEK293
    PDGF R beta Protein is a tyrosine protein kinase that plays an important role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. PDGF R beta Protein, Canine (HEK293, His) is the recombinant canine-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Canine (HEK293, His) is 501 a.a., with molecular weight of 70-100 kDa.
Cat. No. Product Name Effect Purity