2. Immunology/Inflammation
  3. PSMA
  4. PSMA binder-2

PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC).

For research use only. We do not sell to patients.

PSMA binder-2 Chemical Structure

PSMA binder-2 Chemical Structure

CAS No. : 2149567-00-8

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Based on 1 publication(s) in Google Scholar

Other Forms of PSMA binder-2:

PSMA binder-2 Related Antibodies

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Description

PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC)[1][2].

Molecular Weight

630.77

Formula

C33H50N4O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CC1=CC=CC(NC(NCCCC[C@@H](C(OC(C)(C)C)=O)NC(N[C@H](C(OC(C)(C)C)=O)CCC(OC(C)(C)C)=O)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (158.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5854 mL 7.9268 mL 15.8536 mL
5 mM 0.3171 mL 1.5854 mL 3.1707 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5854 mL 7.9268 mL 15.8536 mL 39.6341 mL
5 mM 0.3171 mL 1.5854 mL 3.1707 mL 7.9268 mL
10 mM 0.1585 mL 0.7927 mL 1.5854 mL 3.9634 mL
15 mM 0.1057 mL 0.5285 mL 1.0569 mL 2.6423 mL
20 mM 0.0793 mL 0.3963 mL 0.7927 mL 1.9817 mL
25 mM 0.0634 mL 0.3171 mL 0.6341 mL 1.5854 mL
30 mM 0.0528 mL 0.2642 mL 0.5285 mL 1.3211 mL
40 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.9909 mL
50 mM 0.0317 mL 0.1585 mL 0.3171 mL 0.7927 mL
60 mM 0.0264 mL 0.1321 mL 0.2642 mL 0.6606 mL
80 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4954 mL
100 mM 0.0159 mL 0.0793 mL 0.1585 mL 0.3963 mL
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PSMA binder-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA binder-22149567-00-8PSMA binder2PSMA binder 2PSMAProstate-specific membrane antigenPSMA targeting compoundspharmacokinetic propertiesmetastatic castration-resistant prostate cancermCRPCInhibitorinhibitorinhibit

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