2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. PT1

PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers.

For research use only. We do not sell to patients.

PT1 Chemical Structure

PT1 Chemical Structure

CAS No. : 331002-70-1

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1 mg USD 45 In-stock
5 mg USD 125 In-stock
10 mg USD 190 In-stock
25 mg USD 415 In-stock
50 mg USD 680 In-stock
100 mg USD 1120 In-stock
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Based on 1 publication(s) in Google Scholar

PT1 Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers[1].

Molecular Weight

497.91

Formula

C23H16ClN3O6S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(O)C1=CC(NC(S/C2=C/C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)=NC2=O)=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (41.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0084 mL 10.0420 mL 20.0840 mL
5 mM 0.4017 mL 2.0084 mL 4.0168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.13%

COA (251 KB) HNMR (142 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0084 mL 10.0420 mL 20.0840 mL 50.2099 mL
5 mM 0.4017 mL 2.0084 mL 4.0168 mL 10.0420 mL
10 mM 0.2008 mL 1.0042 mL 2.0084 mL 5.0210 mL
15 mM 0.1339 mL 0.6695 mL 1.3389 mL 3.3473 mL
20 mM 0.1004 mL 0.5021 mL 1.0042 mL 2.5105 mL
25 mM 0.0803 mL 0.4017 mL 0.8034 mL 2.0084 mL
30 mM 0.0669 mL 0.3347 mL 0.6695 mL 1.6737 mL
40 mM 0.0502 mL 0.2510 mL 0.5021 mL 1.2552 mL
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PT1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PT1331002-70-1PT 1PT-1AMPKAMP-activated protein kinaseInhibitorinhibitorinhibit

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