Pyrazoloadenine

Cat. No.: HY-34595 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

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Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity.

For research use only. We do not sell to patients.

Pyrazoloadenine Chemical Structure

CAS No. : 2380-63-4

Size	Price	Stock
10 g	USD 90	Ask For Quote & Lead Time
25 g	USD 180	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
Peritoneal macrophage	CC₅₀	> 64 μM Compound: 3	Cytotoxicity against Swiss mouse peritoneal macrophages assessed as cell detachment, lysis and granulation measured after 5 days by microscopic analysis Cytotoxicity against Swiss mouse peritoneal macrophages assessed as cell detachment, lysis and granulation measured after 5 days by microscopic analysis	[PMID: 33784107]

In Vitro

Pyrazoloadenine inhibits a wide range of protein kinases such as BTK (Bruton’s tyrosine kinase), CDK1/2 (cyclin-dependent kinase 1/2), Src kinase, and RIPK1 (receptor-interacting protein kinase)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

135.13

Formula

C₅H₅N₅

CAS No.

2380-63-4

Appearance

Solid

Color

White to light brown

SMILES

NC1=C2C(NN=C2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (37.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4003 mL	37.0014 mL	74.0028 mL
5 mM	1.4801 mL	7.4003 mL	14.8006 mL
10 mM	0.7400 mL	3.7001 mL	7.4003 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (275 KB) SDS (480 KB)

COA (253 KB) HNMR (116 KB) RP-HPLC (192 KB)

Handling Instructions (2659 KB)

References

[1]. Saha D, et al. Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach. ChemMedChem. 2021 May 18;16(10):1605-1608. [Content Brief]

[2]. SKIPPER HE, et al. Inhibition of experimental neoplasms by 4-aminopyrazolo (3, 4-d) pyrimidine. Proc Soc Exp Biol Med. 1955 Aug;89(4):594-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.4003 mL	37.0014 mL	74.0028 mL	185.0070 mL
	5 mM	1.4801 mL	7.4003 mL	14.8006 mL	37.0014 mL
	10 mM	0.7400 mL	3.7001 mL	7.4003 mL	18.5007 mL
	15 mM	0.4934 mL	2.4668 mL	4.9335 mL	12.3338 mL
	20 mM	0.3700 mL	1.8501 mL	3.7001 mL	9.2504 mL
	25 mM	0.2960 mL	1.4801 mL	2.9601 mL	7.4003 mL
	30 mM	0.2467 mL	1.2334 mL	2.4668 mL	6.1669 mL