Pyrimethamine-d₃

Name: Pyrimethamine-d 3
Brand: MedChemExpress
SKU: HY-18062S
Rating: 5.0 (1 reviews)

Cat. No.: HY-18062S Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pyrimethamine-d₃ is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR)[1][2].

For research use only. We do not sell to patients.

Pyrimethamine-d<sub>3</sub> Chemical Structure

Pyrimethamine-d₃ Chemical Structure

CAS No. : 1189936-99-9

Size	Price	Stock	Quantity
1 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pyrimethamine-d₃:

Pyrimethamine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

251.73

Formula

C₁₂H₁₀D₃ClN₄

CAS No.

1189936-99-9

Unlabeled CAS

58-14-0

Appearance

Solid

Color

White to off-white

SMILES

C(C([2H])([2H])[2H])C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (79.45 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9725 mL	19.8626 mL	39.7251 mL
5 mM	0.7945 mL	3.9725 mL	7.9450 mL
10 mM	0.3973 mL	1.9863 mL	3.9725 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50(2):193-9. [Content Brief]

[3]. Inceboz T, et al. Preparation of (131)I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infectedrats. J Drug Target. 2013 Feb;21(2):175-9. [Content Brief]

[4]. Wright PD, et al. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482(3):188-92. [Content Brief]

[5]. Martins-Duarte ES, et al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133(3):294-9. [Content Brief]

[6]. Taylor WR, et al. Antimalarial drug toxicity: a review. Drug Saf. 2004;27(1):25-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9725 mL	19.8626 mL	39.7251 mL	99.3128 mL
	5 mM	0.7945 mL	3.9725 mL	7.9450 mL	19.8626 mL
	10 mM	0.3973 mL	1.9863 mL	3.9725 mL	9.9313 mL
	15 mM	0.2648 mL	1.3242 mL	2.6483 mL	6.6209 mL
	20 mM	0.1986 mL	0.9931 mL	1.9863 mL	4.9656 mL
	25 mM	0.1589 mL	0.7945 mL	1.5890 mL	3.9725 mL
	30 mM	0.1324 mL	0.6621 mL	1.3242 mL	3.3104 mL
	40 mM	0.0993 mL	0.4966 mL	0.9931 mL	2.4828 mL
	50 mM	0.0795 mL	0.3973 mL	0.7945 mL	1.9863 mL
	60 mM	0.0662 mL	0.3310 mL	0.6621 mL	1.6552 mL