(R)-Monlunabant (Synonyms: (R)-MRI-1891; (R)-INV-202)

Cat. No.: HY-153800A: FAQs
Data Sheet Handling Instructions

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(R)-Monlunabant ((R)-MRI-1891) is a CB1 receptor mediators for research of obesity and metabolic disease

For research use only. We do not sell to patients.

(R)-Monlunabant Chemical Structure

CAS No. : 2765579-76-6

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Other Forms of (R)-Monlunabant:

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CB1 CB2

Biological Activity
Purity & Documentation
References
Customer Review

Description

(R)-Monlunabant ((R)-MRI-1891) is a CB1 receptor mediators for research of obesity and metabolic disease^[1]

Molecular Weight

591.00

Formula

C₂₆H₂₂ClF₃N₆O₃S

CAS No.

2765579-76-6

SMILES

O=S(N/C(N1N=C(C2=CC=C(C=C2)Cl)[C@H](C3=CC=CC=C3)C1)=N/C(NC(C)=O)=N)(C4=CC=C(C=C4)C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (169.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6920 mL	8.4602 mL	16.9205 mL
5 mM	0.3384 mL	1.6920 mL	3.3841 mL
10 mM	0.1692 mL	0.8460 mL	1.6920 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.23 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (4.23 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. George Kunos, et al. Cannabinoid receptor mediating compounds. Patent. US20180273485.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6920 mL	8.4602 mL	16.9205 mL	42.3012 mL
	5 mM	0.3384 mL	1.6920 mL	3.3841 mL	8.4602 mL
	10 mM	0.1692 mL	0.8460 mL	1.6920 mL	4.2301 mL
	15 mM	0.1128 mL	0.5640 mL	1.1280 mL	2.8201 mL
	20 mM	0.0846 mL	0.4230 mL	0.8460 mL	2.1151 mL
	25 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6920 mL
	30 mM	0.0564 mL	0.2820 mL	0.5640 mL	1.4100 mL
	40 mM	0.0423 mL	0.2115 mL	0.4230 mL	1.0575 mL
	50 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8460 mL
	60 mM	0.0282 mL	0.1410 mL	0.2820 mL	0.7050 mL
	80 mM	0.0212 mL	0.1058 mL	0.2115 mL	0.5288 mL
	100 mM	0.0169 mL	0.0846 mL	0.1692 mL	0.4230 mL

(R)-Monlunabant Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Monlunabant2765579-76-6(R)-MRI-1891 (R)-INV-202Cannabinoid ReceptorInhibitorinhibitorinhibit

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