(R)-Necrocide 1

Name: (R)-Necrocide 1
Brand: MedChemExpress
SKU: HY-14307A
Rating: 4.5 (1 reviews)

Cat. No.: HY-14307A Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(R)-Necrocide 1 (compound (R)-38) a potent anticancer agent. (R)-Necrocide 1 has antiproliferative activity.

For research use only. We do not sell to patients.

(R)-Necrocide 1 Chemical Structure

CAS No. : 1247028-62-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 390	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 390	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 355	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2120	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Necrocide 1:

Necrocide 1 Get quote

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Description

(R)-Necrocide 1 (compound (R)-38) a potent anticancer agent. (R)-Necrocide 1 has antiproliferative activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	> 1000 nM Compound: (R)-38	Cytotoxicity against human MCF7 cells after 72 hrs by WST-1 assay Cytotoxicity against human MCF7 cells after 72 hrs by WST-1 assay	[PMID: 20845961]
PC-3	IC₅₀	> 1000 nM Compound: (R)-38	Cytotoxicity against human PC3 cells after 72 hrs by WST-1 assay Cytotoxicity against human PC3 cells after 72 hrs by WST-1 assay	[PMID: 20845961]

Molecular Weight

365.47

Formula

C₂₃H₂₇NO₃

CAS No.

1247028-62-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C1[C@@](C2=CC=C(C=C2)O)(C3CCCCCC3)C4=CC=C(OC)C(C)=C4N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (273.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7362 mL	13.6810 mL	27.3620 mL
5 mM	0.5472 mL	2.7362 mL	5.4724 mL
10 mM	0.2736 mL	1.3681 mL	2.7362 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.84 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.84 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (6.84 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (261 KB) HNMR (141 KB) RP-HPLC (97 KB) LCMS (231 KB)

Handling Instructions (2659 KB)

References

[1]. Christensen MK, et, al. Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. J Med Chem. 2010 Oct 14;53(19):7140-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7362 mL	13.6810 mL	27.3620 mL	68.4051 mL
	5 mM	0.5472 mL	2.7362 mL	5.4724 mL	13.6810 mL
	10 mM	0.2736 mL	1.3681 mL	2.7362 mL	6.8405 mL
	15 mM	0.1824 mL	0.9121 mL	1.8241 mL	4.5603 mL
	20 mM	0.1368 mL	0.6841 mL	1.3681 mL	3.4203 mL
	25 mM	0.1094 mL	0.5472 mL	1.0945 mL	2.7362 mL
	30 mM	0.0912 mL	0.4560 mL	0.9121 mL	2.2802 mL
	40 mM	0.0684 mL	0.3420 mL	0.6841 mL	1.7101 mL
	50 mM	0.0547 mL	0.2736 mL	0.5472 mL	1.3681 mL
	60 mM	0.0456 mL	0.2280 mL	0.4560 mL	1.1401 mL
	80 mM	0.0342 mL	0.1710 mL	0.3420 mL	0.8551 mL
	100 mM	0.0274 mL	0.1368 mL	0.2736 mL	0.6841 mL

(R)-Necrocide 1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Necrocide 11247028-62-1OthersaticancerMCF-7PC3Inhibitorinhibitorinhibit

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(R)-Necrocide 1

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Complete Stock Solution Preparation Table

(R)-Necrocide 1 Related Classifications

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