2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. (R)-SCH 546738

(R)-SCH 546738 is the R-isomer of SCH 546738 (HY-10017). SCH 546738 is an orally active and non-competitive antagonist for CXCR3 with Ki of 0.4 nM for human CXCR3 receptor.

For research use only. We do not sell to patients.

(R)-SCH 546738 Chemical Structure

(R)-SCH 546738 Chemical Structure

CAS No. : 2181148-54-7

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10 mg USD 460 In-stock
50 mg USD 1100 In-stock
100 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-SCH 546738:

(R)-SCH 546738 Related Antibodies

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Description

(R)-SCH 546738 is the R-isomer of SCH 546738 (HY-10017). SCH 546738 is an orally active and non-competitive antagonist for CXCR3 with Ki of 0.4 nM for human CXCR3 receptor[1].

Molecular Weight

492.44

Formula

C23H31Cl2N7O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N)C1=NC(Cl)=C(N2CCN(C3CCN(CC4=CC=C(Cl)C=C4)CC3)[C@H](CC)C2)N=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0307 mL 10.1535 mL 20.3070 mL
5 mM 0.4061 mL 2.0307 mL 4.0614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.75%

COA (246 KB) HNMR (268 KB) RP-HPLC (287 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0307 mL 10.1535 mL 20.3070 mL 50.7676 mL
5 mM 0.4061 mL 2.0307 mL 4.0614 mL 10.1535 mL
10 mM 0.2031 mL 1.0154 mL 2.0307 mL 5.0768 mL
15 mM 0.1354 mL 0.6769 mL 1.3538 mL 3.3845 mL
20 mM 0.1015 mL 0.5077 mL 1.0154 mL 2.5384 mL
25 mM 0.0812 mL 0.4061 mL 0.8123 mL 2.0307 mL
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(R)-SCH 546738 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-SCH 5467382181148-54-7CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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