(Rac)-Bepotastine besilate

Cat. No.: HY-A0015A Purity: 99.52%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research.

For research use only. We do not sell to patients.

(Rac)-Bepotastine besilate Chemical Structure

CAS No. : 1415692-17-9

Size	Price	Stock	Quantity
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-Bepotastine besilate:

Bepotastine besilate In-stock

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

547.06

Formula

C₂₇H₃₁ClN₂O₆S

CAS No.

1415692-17-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=CC=CC=C1)(O)=O.O=C(CCCN2CCC(CC2)OC(C3=NC=CC=C3)C4=CC=C(C=C4)Cl)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (91.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8280 mL	9.1398 mL	18.2795 mL
5 mM	0.3656 mL	1.8280 mL	3.6559 mL
10 mM	0.1828 mL	0.9140 mL	1.8280 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) HNMR (282 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91(1):85-91. [Content Brief]

[2]. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. [Content Brief]

[3]. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145(4):277-82. [Content Brief]

[4]. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26(10):2329-38. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8280 mL	9.1398 mL	18.2795 mL	45.6988 mL
	5 mM	0.3656 mL	1.8280 mL	3.6559 mL	9.1398 mL
	10 mM	0.1828 mL	0.9140 mL	1.8280 mL	4.5699 mL
	15 mM	0.1219 mL	0.6093 mL	1.2186 mL	3.0466 mL
	20 mM	0.0914 mL	0.4570 mL	0.9140 mL	2.2849 mL
	25 mM	0.0731 mL	0.3656 mL	0.7312 mL	1.8280 mL
	30 mM	0.0609 mL	0.3047 mL	0.6093 mL	1.5233 mL
	40 mM	0.0457 mL	0.2285 mL	0.4570 mL	1.1425 mL
	50 mM	0.0366 mL	0.1828 mL	0.3656 mL	0.9140 mL
	60 mM	0.0305 mL	0.1523 mL	0.3047 mL	0.7616 mL
	80 mM	0.0228 mL	0.1142 mL	0.2285 mL	0.5712 mL