(Rac)-Taltobulin intermediate-1

Cat. No.: HY-41045 Purity: 99.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(Rac)-Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis.

For research use only. We do not sell to patients.

(Rac)-Taltobulin intermediate-1 Chemical Structure

CAS No. : 676487-35-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 295	In-stock	Estimated Time of Arrival: December 31
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1 g		Get quote

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Other Forms of (Rac)-Taltobulin intermediate-1:

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

307.38

Formula

C₁₇H₂₅NO₄

CAS No.

676487-35-7

Appearance

Solid

Color

White to off-white

SMILES

OC(C(N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (325.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2533 mL	16.2665 mL	32.5330 mL
5 mM	0.6507 mL	3.2533 mL	6.5066 mL
10 mM	0.3253 mL	1.6267 mL	3.2533 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (252 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2533 mL	16.2665 mL	32.5330 mL	81.3326 mL
	5 mM	0.6507 mL	3.2533 mL	6.5066 mL	16.2665 mL
	10 mM	0.3253 mL	1.6267 mL	3.2533 mL	8.1333 mL
	15 mM	0.2169 mL	1.0844 mL	2.1689 mL	5.4222 mL
	20 mM	0.1627 mL	0.8133 mL	1.6267 mL	4.0666 mL
	25 mM	0.1301 mL	0.6507 mL	1.3013 mL	3.2533 mL
	30 mM	0.1084 mL	0.5422 mL	1.0844 mL	2.7111 mL
	40 mM	0.0813 mL	0.4067 mL	0.8133 mL	2.0333 mL
	50 mM	0.0651 mL	0.3253 mL	0.6507 mL	1.6267 mL
	60 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL
	80 mM	0.0407 mL	0.2033 mL	0.4067 mL	1.0167 mL
	100 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL