Ractopamine

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Ractopamine is a potent β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β₁AR and β₂AR. Ractopamine is linked to protein metabolism. Ractopamine is structurally similar to the natural catecholamines epinephrine and norepinephrine, and binds with high affinity to βAR in pig adipose and muscle tissue. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

For research use only. We do not sell to patients.

Ractopamine Chemical Structure

CAS No. : 97825-25-7

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α adrenergic receptor β adrenergic receptor

Biological Activity
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Description

IC₅₀ & Target^[3]

pig β₁AR

~25 nM (Kd)

pig β₂AR

~25 nM (Kd)

In Vivo

Ractopamine consistently increases muscle protein accretion in pigs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

301.38

Formula

C₁₈H₂₃NO₃

CAS No.

97825-25-7

SMILES

OC(CNC(C)CCC1=CC=C(O)C=C1)C2=CC=C(O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Athayde NB, et al. Stress susceptibility in pigs supplemented with ractopamine. J Anim Sci. 2013;91(9):4180-4187. [Content Brief]

[2]. Anderson PT, et al. Ractopamine increases total and myofibrillar protein synthesis in cultured rat myotubes. J Nutr. 1990;120(12):1677-1683. [Content Brief]

[3]. S. E. Mills, Biological basis of the ractopamine response, Journal of Animal Science, Volume 80, Issue E-suppl_2, 2002, Pages E28–E32

Ractopamine Related Classifications

Metabolic Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ractopamine97825-25-7Adrenergic ReceptorBeta ReceptorβARadiposemuscletissue growthprotein metabolismpigInhibitorinhibitorinhibit

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