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  3. ASGR2/ASGPR2 Protein, Mouse (His-SUMO)

ASGR2/ASGPR2 Protein, Mouse (His-SUMO)

Cat. No.: HY-P72091
Handling Instructions

ASGR2/ASGPR2 proteins are critical in cellular processes, mediating the endocytosis of desialylated plasma glycoproteins. It recognizes terminal galactose and N-acetylgalactosamine, promotes ligand internalization, and forms complexes that are transported to sorting organelles. ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived ASGR2/ASGPR2 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is 222 a.a., with molecular weight of ~45.9 kDa.

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Description

ASGR2/ASGPR2 proteins are critical in cellular processes, mediating the endocytosis of desialylated plasma glycoproteins. It recognizes terminal galactose and N-acetylgalactosamine, promotes ligand internalization, and forms complexes that are transported to sorting organelles. ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived ASGR2/ASGPR2 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is 222 a.a., with molecular weight of ~45.9 kDa.

Background

ASGR2/ASGPR2 Protein plays a crucial role in cellular processes by mediating the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. Recognizing terminal galactose and N-acetylgalactosamine units, the receptor facilitates the internalization of ligands, forming a complex that is subsequently transported to a sorting organelle. Within this organelle, the receptor and ligand dissociate, and the receptor is then recycled back to the cell membrane surface. ASGR2/ASGPR2's engagement in these dynamic processes highlights its significance in the cellular handling of glycoproteins and contributes to the regulation of cellular homeostasis. The protein also interacts with LASS2, further expanding its molecular associations and potential implications in cellular signaling or coordination.

Species

Mouse

Source

E. coli

Tag

N-10*His;N-SUMO

Accession

P24721 (Q80-H301)

Gene ID
Molecular Construction
N-term
10*His-SUMO
ASGR2 (Q80-H301)
Accession # P24721
C-term
Synonyms
Asgr2; Asgr-2; Asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2
AA Sequence

QSIQLQEEFRTLKETFSNFSSSTLMEFGALDTLGGSTNAILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRTLTCQLAYFQSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQYCQLENAHLLVINSREEQDFVVKHRSQFHIWIGLTDRDGSWKWVDGTDYRSNYRNWAFTQPDNWQGHEQGGGEDCAEILSDGHWNDNFCQQVNRWVCEKRRNITH

Molecular Weight

Approximately 45.9 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ASGR2/ASGPR2 Protein, Mouse (His-SUMO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
ASGR2/ASGPR2 Protein, Mouse (His-SUMO)
Cat. No.:
HY-P72091
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