Cadherin-13 Protein, Mouse (HEK293, Fc)

Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. These proteins may act as negative regulators of neural cell growth. In contrast to classical cadherins, the homodimerization of Cadherin-13 in trans does not occur through the cadherin EC1 domain strand-swapping mechanism. Instead, it takes place through a homophilic adhesive interface, bringing together two elongated EC1-EC2 domains in close proximity to their Ca2+-binding sites, forming a distinctive tetrahedral, X-like shape. Cadherin-13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Cadherin-13 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-13 Protein, Mouse (HEK293, Fc) is 692 a.a., with molecular weight of ~100.6 kDa.

Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. These proteins may act as negative regulators of neural cell growth. In contrast to classical cadherins, the homodimerization of Cadherin-13 in trans does not occur through the cadherin EC1 domain strand-swapping mechanism. Instead, it takes place through a homophilic adhesive interface, bringing together two elongated EC1-EC2 domains in close proximity to their Ca2+-binding sites, forming a distinctive tetrahedral, X-like shape.

Mouse

HEK293

C-hFc

Q9WTR5 (M1-A692)

12554  [NCBI]

Approximately 100.6 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.