1. Recombinant Proteins
  2. Cytokines and Growth Factors CD Antigens Fluorescent-labeled Recombinant Proteins
  3. Interleukin & Receptors NK Cell CD Proteins
  4. IL-15 Receptor IL-15R alpha/CD215
  5. IL-15R alpha/CD215
  6. FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc)

FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc)

Cat. No.: HY-P701298
Handling Instructions

IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag.

For research use only. We do not sell to patients.

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Description

IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag.

Background

IL-15R alpha Protein stands out as a high-affinity receptor for interleukin-15, as evidenced by studies. This receptor exhibits the remarkable capability to signal both in cis and trans, where IL15R from one subset of cells presents interleukin-15 to neighboring IL2RG-expressing cells (By similarity). Notably, in neutrophils, IL-15R alpha Protein binds to and activates the kinase SYK in response to interleukin-15 stimulation, playing a critical role in IL-15-induced phagocytosis in a SYK-dependent manner. It's important to note that the expression of different isoforms may introduce variations or interference with signal transduction processes. Despite its high affinity for interleukin-15, it is specified that IL-15R alpha Protein does not directly bind to IL15.

Species

Human

Source

HEK293

Tag

Fc

Accession

Q13261-1 (I31-T205)

Gene ID

3601

Synonyms
IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha
Molecular Weight

60-80 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc)
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HY-P701298
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