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  4. IZUMO4 Protein, Human (HEK293, Fc)

IZUMO4 Protein, Human (HEK293, Fc)

Cat. No.: HY-P70849
Handling Instructions

IZUMO4 protein is a member of IZUMO family, and is usually expressed in testis, mature spermatozoa and nonreproductive tissues. IZUMO4 is involved in sperm-egg membrane fusion. Notably, IZUMO4 lacks a transmembrane domain. IZUMO4 Protein, Human (HEK293, Fc) is the recombinant human-derived IZUMO4 protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

IZUMO4 protein is a member of IZUMO family, and is usually expressed in testis, mature spermatozoa and nonreproductive tissues. IZUMO4 is involved in sperm-egg membrane fusion. Notably, IZUMO4 lacks a transmembrane domain[1][2][3]. IZUMO4 Protein, Human (HEK293, Fc) is the recombinant human-derived IZUMO4 protein, expressed by HEK293 , with C-hFc labeled tag.
Background

IZUMO4 protein is a member of IZUMO family, and is usually expressed in testis, mature spermatozoa and nonreproductive tissues. IZUMO4 is involved in sperm-egg membrane fusion. Notably, IZUMO4 lacks a transmembrane domain[1][2][3].
Species

Human
Source

HEK293
Tag

C-hFc
Accession

Q1ZYL8-2 (H16-H214)
Gene ID
Synonyms
Sperm 22 kDa protein c113; IZUMO4; C19orf36; UNQ831/PRO1758
AA Sequence

HGCLHCHSNFSKKFSFYRHHVNFKSWWVGDIPVSGALLTDWSDDTMKELHLAIPAKITREKLDQVATAVYQMMDQLYQGKMYFPGYFPNELRNIFREQVHLIQNAIIESRIDCQHRCGIFQYETISCNNCTDSHVACFGYNCESSAQWKSAVQGLLNYINNWHKQDTSMSLVSPALRCLEPPHLANLTLEDAAECLKQH

Molecular Weight

Approximately 60.0 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IZUMO4 Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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