2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins
  6. Neuregulin-1 (NRG1)
  7. NRG1-beta 2 Protein, Human (HEK293, His)

NRG1-beta 2 Protein, Human (HEK293, His)

Cat. No.: HY-P73744
Handling Instructions

NRG1-beta 2 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of NRG1-beta 2 Protein, Human (HEK293, His) is 219 a.a., with molecular weight of ~25.3 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

NRG1-beta 2 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of NRG1-beta 2 Protein, Human (HEK293, His) is 219 a.a., with molecular weight of ~25.3 kDa.
Background

HRG1-β1 activates HER2/HER3 signaling and up-regulate Fn14 gene expression in parental MCF7 cells. HRG1-β1-mediated Fn14 up-regulation in MCF7/HER2-18 cells is required for maximal MMP-9 production.
Species

Human
Source

HEK293
Tag

C-His
Accession

Q02297-7/NP_001153480 (S20-K238)
Gene ID
Molecular Construction
N-term
NRG1-beta 2 (S20-K238)
Accession # Q02297-7/NP_001153480
His
C-term
Synonyms
Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1
Molecular Weight

Approximately 25.3 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NRG1-beta 2 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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