SRFBP1 Protein, Human (sf9, His-GST)

The SRFBP1 protein is a potential regulator of multiple cellular processes and is involved in aging-associated transcriptional activation of cardiac genes and the biosynthesis/processing of SLC2A4 in adipocytes. Its multifaceted effects extend into metabolic pathways, involving interactions with SRF and formation of complexes with SRF cofactors ARID2, MYOCD, and NKX2-5, highlighting its role in transcriptional regulation. SRFBP1 Protein, Human (sf9, His-GST) is the recombinant human-derived SRFBP1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SRFBP1 Protein, Human (sf9, His-GST) is 429 a.a., with molecular weight of ~69 kDa.

SRFBP1 Protein emerges as a potential regulator in diverse cellular processes, with implications in the aging-associated transcriptional activation of cardiac genes. Additionally, it may play a role in the biosynthesis and/or processing of SLC2A4 in adipose cells, suggesting a multifaceted involvement in metabolic pathways. Interactions with the transcription factor SRF, as well as the formation of complexes with SRF cofactors ARID2, MYOCD, and NKX2-5, highlight SRFBP1's role in transcriptional regulation. Moreover, its interaction with the N-terminus of SLC2A4 suggests a potential role in the modulation of glucose transport processes. Unraveling the specific mechanisms governing SRFBP1's functions could provide valuable insights into its role in cardiac aging, metabolic regulation, and transcriptional control, paving the way for a more comprehensive understanding of its cellular impact.

Human

Sf9 insect cells

N-His;N-GST

Q8NEF9 (M1-D429)

153443  [NCBI]

Approximately 69 kDa

Greater than 95% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% Glycerol, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.