Thrombomodulin Protein, Mouse (HEK293, His)

Thrombomodulin is an endothelial cell receptor that forms a 1:1 complex with thrombin and is essential for the activation of protein C to protein Ca.Protein Ca cleaves coagulation cascade cofactors and reduces thrombin generation.Thrombomodulin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Thrombomodulin protein, expressed by HEK293 , with C-6*His labeled tag.

Thrombomodulin Protein serves as a specific endothelial cell receptor, engaging in a 1:1 stoichiometric complex with thrombin. This complex plays a pivotal role in the conversion of protein C to its activated form, protein Ca. Upon activation, protein Ca functions to cleave the activated cofactors of the coagulation cascade, namely factor Va and factor VIIIa, leading to a reduction in the overall production of thrombin. Thrombomodulin's interactions with ITGAL, ITGAM, and ITGB2 further emphasize its role in mediating cellular interactions, possibly influencing immune responses. This intricate interplay underscores the significance of Thrombomodulin in modulating the coagulation pathway and maintaining hemostatic balance.

Mouse

HEK293

C-6*His

P15306 (L17-S517)

21824  [NCBI]

LSALAKLQPTGSQCVEHECFALFQGPATFLDASQACQRLQGHLMTVRSSVAADVISLLLSQSSMDLGPWIGLQLPQGCDDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQTAPLCGPLCVTVSTATEAAPGEPAWEEKPCETETQGFLCEFYFTASCRPLTVNTRDPEAAHISSTYNTPFGVSGADFQTLPVGSSAAVEPLGLELVCRAPPGTSEGHWAWEATGAWNCSVENGGCEYLCNRSTNEPRCLCPRDMDLQADGRSCARPVVQSCNELCEHFCVSNAEVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCVNTKGGFECFCYDGYELVDGECVELLDPCFGSNCEFQCQPVSPTDYRCICAPGFAPKPDEPHKCEMFCNETSCPADCDPNSPTVCECPEGFILDEGSVCTDIDECSQGECFTSECRNFPGSYECICGPDTALAGQISKDCDPIPVREDTKEEEGSGEPPVSPTPGSPTGPPSARPVHS

85-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0 .

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.