2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Leukotriene Receptor Lipoxygenase
  4. REV 5901

REV 5901 is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 is also a 5-lipoxygenase inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved.

For research use only. We do not sell to patients.

REV 5901 Chemical Structure

REV 5901 Chemical Structure

CAS No. : 101910-24-1

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Based on 1 publication(s) in Google Scholar

Other Forms of REV 5901:

REV 5901 Related Antibodies

Top Publications Citing Use of Products

View All Leukotriene Receptor Isoform Specific Products:

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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5-LOX 12-LOX 15-LOX

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  • Purity & Documentation

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Description

REV 5901 is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 is also a 5-lipoxygenase inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved[1][2].

IC50 & Target

Ki: 0.7 μM (leukotriene receptor)[1]
[2]
Molecular Weight

335.44

Formula

C22H25NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCCCC)C1=CC=CC(OCC2=NC3=CC=CC=C3C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 36 mg/mL (107.32 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9812 mL 14.9058 mL 29.8116 mL
5 mM 0.5962 mL 2.9812 mL 5.9623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.9812 mL 14.9058 mL 29.8116 mL 74.5290 mL
5 mM 0.5962 mL 2.9812 mL 5.9623 mL 14.9058 mL
10 mM 0.2981 mL 1.4906 mL 2.9812 mL 7.4529 mL
15 mM 0.1987 mL 0.9937 mL 1.9874 mL 4.9686 mL
20 mM 0.1491 mL 0.7453 mL 1.4906 mL 3.7264 mL
25 mM 0.1192 mL 0.5962 mL 1.1925 mL 2.9812 mL
30 mM 0.0994 mL 0.4969 mL 0.9937 mL 2.4843 mL
40 mM 0.0745 mL 0.3726 mL 0.7453 mL 1.8632 mL
50 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.4906 mL
60 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2421 mL
80 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9316 mL
100 mM 0.0298 mL 0.1491 mL 0.2981 mL 0.7453 mL
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REV 5901 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

REV 5901101910-24-1REV5901REV-5901Leukotriene ReceptorLipoxygenaseLOXInhibitorinhibitorinhibit

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