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  4. Rimexolone

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.

For research use only. We do not sell to patients.

Rimexolone Chemical Structure

Rimexolone Chemical Structure

CAS No. : 49697-38-3

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Based on 1 publication(s) in Google Scholar

Rimexolone Related Antibodies

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Description

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
0.68 μM
Compound: Rimexolone
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
1.6 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
[PMID: 20966043]
HepG2 EC50
4 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
In Vitro

Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rimexolone Related Antibodies
In Vivo

Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1]
Dosage: 5, 25, 50, 150, 250, 450 μg/mouse
Administration: Intraarticular injection, once
Result: Suppressed the arthritis in a dose-dependent manner.
Significantly prevented osteophyte formation at 450 and 150 μg.
Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
Clinical Trial
Molecular Weight

370.52

Formula

C24H34O3
CAS No.
SMILES

C[C@@]12[C@](C(CC)=O)(C)[C@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Rimexolone Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimexolone49697-38-3Org 6216 RimexelOrg6216Org-6216Othersanti-inflammatory activityocular inflammationminimal systematic effectsarthritisInhibitorinhibitorinhibit

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