2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. RO0711401

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.

For research use only. We do not sell to patients.

RO0711401 Chemical Structure

RO0711401 Chemical Structure

CAS No. : 714971-87-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 90 In-stock
25 mg USD 190 In-stock
50 mg USD 305 In-stock
100 mg USD 500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

RO0711401 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE RO0711401

View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].

IC50 & Target[1][2]

mGluR1

56 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
CHO EC50
202 nM
Compound: 14a
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology
[PMID: 19233648]
HEK293 EC50
56 nM
Compound: 14a
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay
[PMID: 19233648]
In Vivo

RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days[1].
Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spinocerebellar ataxia type 1 (SCA1) mice (30-week old)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
Molecular Weight

360.29

Formula

C18H11F3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(C(F)(F)F)=CO1)C2C3=C(C=CC=C3)OC4=C2C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7755 mL 13.8777 mL 27.7554 mL
5 mM 0.5551 mL 2.7755 mL 5.5511 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7755 mL 13.8777 mL 27.7554 mL 69.3885 mL
5 mM 0.5551 mL 2.7755 mL 5.5511 mL 13.8777 mL
10 mM 0.2776 mL 1.3878 mL 2.7755 mL 6.9389 mL
15 mM 0.1850 mL 0.9252 mL 1.8504 mL 4.6259 mL
20 mM 0.1388 mL 0.6939 mL 1.3878 mL 3.4694 mL
25 mM 0.1110 mL 0.5551 mL 1.1102 mL 2.7755 mL
30 mM 0.0925 mL 0.4626 mL 0.9252 mL 2.3130 mL
40 mM 0.0694 mL 0.3469 mL 0.6939 mL 1.7347 mL
50 mM 0.0555 mL 0.2776 mL 0.5551 mL 1.3878 mL
60 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1565 mL
80 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8674 mL
100 mM 0.0278 mL 0.1388 mL 0.2776 mL 0.6939 mL
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RO0711401 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO0711401714971-87-6RO 0711401RO-0711401mGluRMetabotropic glutamate receptorsmGlu1PAMoralInhibitorinhibitorinhibit

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