2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Romifidine

Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo.

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Romifidine Chemical Structure

Romifidine Chemical Structure

CAS No. : 65896-16-4

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Based on 1 publication(s) in Google Scholar

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Description

Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].

In Vivo

Romifidine (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1].
Romifidine (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

258.09

Formula

C9H9BrFN3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(NC2=NCCN2)C(Br)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (968.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8746 mL 19.3731 mL 38.7462 mL
5 mM 0.7749 mL 3.8746 mL 7.7492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8746 mL 19.3731 mL 38.7462 mL 96.8654 mL
5 mM 0.7749 mL 3.8746 mL 7.7492 mL 19.3731 mL
10 mM 0.3875 mL 1.9373 mL 3.8746 mL 9.6865 mL
15 mM 0.2583 mL 1.2915 mL 2.5831 mL 6.4577 mL
20 mM 0.1937 mL 0.9687 mL 1.9373 mL 4.8433 mL
25 mM 0.1550 mL 0.7749 mL 1.5498 mL 3.8746 mL
30 mM 0.1292 mL 0.6458 mL 1.2915 mL 3.2288 mL
40 mM 0.0969 mL 0.4843 mL 0.9687 mL 2.4216 mL
50 mM 0.0775 mL 0.3875 mL 0.7749 mL 1.9373 mL
60 mM 0.0646 mL 0.3229 mL 0.6458 mL 1.6144 mL
80 mM 0.0484 mL 0.2422 mL 0.4843 mL 1.2108 mL
100 mM 0.0387 mL 0.1937 mL 0.3875 mL 0.9687 mL
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Romifidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romifidine65896-16-4Adrenergic ReceptorBeta ReceptordetomidinesedationponyhorseInhibitorinhibitorinhibit

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