Rupintrivir (Synonyms: AG7088)

Name: Rupintrivir
Brand: MedChemExpress
SKU: HY-106161
Rating: 5.0 (5 reviews)

Cat. No.: HY-106161 Purity: 99.36%: FAQs
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Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

For research use only. We do not sell to patients.

Rupintrivir Chemical Structure

CAS No. : 223537-30-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 461	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 461	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 175	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Rupintrivir:

Rupintrivir-d₇ Get quote

5 Publications Citing Use of MCE Rupintrivir

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	EC₅₀	14 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HRV14 with 3C protease T129A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	14 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T131A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HRV14 with 3C protease T131A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	14 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease Y139H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HRV14 with 3C protease Y139H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	140 nM Compound: AG-7088	Antiviral activity against HRV2 with 3C protease E3E/G, A103A/V, N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 9 passages for 62 days by XTT assay Antiviral activity against HRV2 with 3C protease E3E/G, A103A/V, N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 9 passages for 62 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	15 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HRV14 with 3C protease T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	152 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129T/A, T131T/A, T143P/S mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 passages for 14 days by XTT assay Antiviral activity against HRV14 with 3C protease T129T/A, T131T/A, T143P/S mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 passages for 14 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	19 nM Compound: AG-7088	Antiviral activity against wild type HRV Hanks infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 days by plaque reduction assay Antiviral activity against wild type HRV Hanks infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 days by plaque reduction assay	[PMID: 17908951]
H1-HeLa	EC₅₀	21 nM Compound: AG-7088	Antiviral activity against wild type HRV14 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against wild type HRV14 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	227 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129A, T131T/A, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 passages for 17 days by XTT assay Antiviral activity against HRV14 with 3C protease T129A, T131T/A, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 passages for 17 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	24 nM Compound: AG-7088	Antiviral activity against wild type HRV39 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against wild type HRV39 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	268 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129A, T131A, Y139H, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HRV14 with 3C protease T129A, T131A, Y139H, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	30 nM Compound: AG-7088	Antiviral activity against wild type HRV2 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay Antiviral activity against wild type HRV2 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	324 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129A, T131A, T143P, Y139Y/H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 10 passages for 55 days by XTT assay Antiviral activity against HRV14 with 3C protease T129A, T131A, T143P, Y139Y/H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 10 passages for 55 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	335 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease A121A/V, T129A, T131A, T143P, Y139Y/H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 11 passages for 65 days by XTT assay Antiviral activity against HRV14 with 3C protease A121A/V, T129A, T131A, T143P, Y139Y/H mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 11 passages for 65 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	34 nM Compound: AG-7088	Antiviral activity against HRV2 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 passages for 17 days by XTT assay Antiviral activity against HRV2 infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 3 passages for 17 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	414 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease A121A/V, T129A, T131A, N132S, Y139Y/H, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 12 passages for 72 days by XTT assay Antiviral activity against HRV14 with 3C protease A121A/V, T129A, T131A, N132S, Y139Y/H, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 12 passages for 72 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	44 nM Compound: AG-7088	Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 passages for 24 days by XTT assay Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 4 passages for 24 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	51 nM Compound: AG-7088	Antiviral activity against HRV Hanks with 3C protease T130A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 6 passages for 40 days by plaque reduction assay Antiviral activity against HRV Hanks with 3C protease T130A mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 6 passages for 40 days by plaque reduction assay	[PMID: 17908951]
H1-HeLa	EC₅₀	57 nM Compound: AG-7088	Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 30 days by XTT assay Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 30 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	67 nM Compound: AG-7088	Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 6 passages for 37 days by XTT assay Antiviral activity against HRV2 with 3C protease N165T mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 6 passages for 37 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	83 nM Compound: AG-7088	Antiviral activity against HRV39 with 3C protease N130NB/K, L136/F mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 29 days by XTT assay Antiviral activity against HRV39 with 3C protease N130NB/K, L136/F mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 29 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	94 nM Compound: AG-7088	Antiviral activity against HRV39 with 3C protease S105T, N130K, L136F mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 9 passages for 50 days by XTT assay Antiviral activity against HRV39 with 3C protease S105T, N130K, L136F mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 9 passages for 50 days by XTT assay	[PMID: 17908951]
H1-HeLa	EC₅₀	96 nM Compound: AG-7088	Antiviral activity against HRV14 with 3C protease T129A, T131T/A, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 22 days by XTT assay Antiviral activity against HRV14 with 3C protease T129A, T131T/A, T143P mutation infected in human H1-HeLa cells assessed as virus-induced cytopathic effect after 5 passages for 22 days by XTT assay	[PMID: 17908951]
HeLa	CC₅₀	> 50 μM Compound: Rupintrivir	Cytotoxicity against human HeLa cells assessed as growth inhibition after 2 days by SRB assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 2 days by SRB assay	[PMID: 30676026]
HeLa	EC₅₀	0.27 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVA16 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus CVA16 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	0.36 μM Compound: AG-7088	Antiviral activity against Human enterovirus Echo9 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus Echo9 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	0.372 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB4 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus CVB4 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	0.561 μM Compound: AG-7088	Antiviral activity against Human enterovirus EV71 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus EV71 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	0.783 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB2 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus CVB2 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	1.2 ng/mL Compound: Rupintrivir	Antirhinoviral activity against Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
HeLa	EC₅₀	1.2 ng/mL Compound: Rupintrivir	Antirhinoviral activity against antiviral-resistant Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against antiviral-resistant Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
HeLa	EC₅₀	1.247 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB1 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay Antiviral activity against Human enterovirus CVB1 infected in human HeLa cells after 2 to 4 days by formazan dye reduction assay	[PMID: 19015331]
HeLa	EC₅₀	1.5 ng/mL Compound: Rupintrivir	Antirhinoviral activity against major receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against major receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
HeLa	EC₅₀	2 ng/mL Compound: Rupintrivir	Antirhinoviral activity against Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against Human rhinovirus A infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
HeLa	EC₅₀	2 ng/mL Compound: Rupintrivir	Antirhinoviral activity against antiviral-resistant Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against antiviral-resistant Human rhinovirus B infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
HeLa	EC₅₀	3 ng/mL Compound: Rupintrivir	Antirhinoviral activity against minor receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay Antirhinoviral activity against minor receptor-resistant Human rhinovirus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 24900468]
RD	EC₅₀	0.009 μM Compound: 2H; AG7088	Antiviral activity against Enterovirus 71/Shenzhen/120F1/09 infected in human RD cells assessed as reduction in virus induced cell death after 72 hrs by CCK-8 assay Antiviral activity against Enterovirus 71/Shenzhen/120F1/09 infected in human RD cells assessed as reduction in virus induced cell death after 72 hrs by CCK-8 assay	[PMID: 27234148]
Vero	CC₅₀	> 50 μM Compound: Rupintrivir	Cytotoxicity against African green monkey Vero cells assessed as growth inhibition after 2 days by SRB assay Cytotoxicity against African green monkey Vero cells assessed as growth inhibition after 2 days by SRB assay	[PMID: 30676026]
Vero	EC₅₀	0.419 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVA16 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus CVA16 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]
Vero	EC₅₀	0.481 μM Compound: AG-7088	Antiviral activity against Human enterovirus Echo9 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus Echo9 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]
Vero	EC₅₀	0.791 μM Compound: AG-7088	Antiviral activity against Human enterovirus EV71 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus EV71 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]
Vero	EC₅₀	0.843 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB4 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus CVB4 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]
Vero	EC₅₀	0.982 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB2 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus CVB2 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]
Vero	EC₅₀	1.725 μM Compound: AG-7088	Antiviral activity against Human enterovirus CVB1 infected in Vero cells after 4 to 7 days by plaque reduction assay Antiviral activity against Human enterovirus CVB1 infected in Vero cells after 4 to 7 days by plaque reduction assay	[PMID: 19015331]

In Vitro

In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC₅₀) of 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC₉₀ of 0.082 μM (range, 0.018 to 0.261 μM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rupintrivirvr (AG7088) reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

598.66

Formula

C₃₁H₃₉FN₄O₇

CAS No.

223537-30-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)/C=C/[C@@H](NC([C@H](CC1=CC=C(F)C=C1)CC([C@@H](NC(C2=NOC(C)=C2)=O)C(C)C)=O)=O)C[C@H]3C(NCC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (83.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6704 mL	8.3520 mL	16.7040 mL
5 mM	0.3341 mL	1.6704 mL	3.3408 mL
10 mM	0.1670 mL	0.8352 mL	1.6704 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.67 mg/mL (2.79 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. Patick AK, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. [Content Brief]

[2]. Danov O, et al. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res. 2019 Oct 22;20(1):228. [Content Brief]

[3]. Dragovich PS, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem. 1999 Apr 8;42(7):1203-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6704 mL	8.3520 mL	16.7040 mL	41.7599 mL
	5 mM	0.3341 mL	1.6704 mL	3.3408 mL	8.3520 mL
	10 mM	0.1670 mL	0.8352 mL	1.6704 mL	4.1760 mL
	15 mM	0.1114 mL	0.5568 mL	1.1136 mL	2.7840 mL
	20 mM	0.0835 mL	0.4176 mL	0.8352 mL	2.0880 mL
	25 mM	0.0668 mL	0.3341 mL	0.6682 mL	1.6704 mL
	30 mM	0.0557 mL	0.2784 mL	0.5568 mL	1.3920 mL
	40 mM	0.0418 mL	0.2088 mL	0.4176 mL	1.0440 mL
	50 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL
	60 mM	0.0278 mL	0.1392 mL	0.2784 mL	0.6960 mL
	80 mM	0.0209 mL	0.1044 mL	0.2088 mL	0.5220 mL

Rupintrivir Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rupintrivir (Synonyms: AG7088)

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Rupintrivir (Synonyms: AG7088)

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