2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. (S)-C33

(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research.

For research use only. We do not sell to patients.

(S)-C33 Chemical Structure

(S)-C33 Chemical Structure

CAS No. : 2066488-39-7

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(S)-C33 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

(S)-C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research[1].

IC50 & Target

PDE9A

11 ± 4 nM (IC50)

PDE5A1

366 ± 38 nM (IC50)

PDE1B

554 ± 64 nM (IC50)

PDE4D2

1.3 ± 0.1 μM (IC50)

PDE10A1

2.3 ± 0.3 μM (IC50)

PDE2A

2.4 ± 0.5 μM (IC50)

Molecular Weight

357.84

Formula

C18H20ClN5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (279.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7945 mL 13.9727 mL 27.9454 mL
5 mM 0.5589 mL 2.7945 mL 5.5891 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7945 mL 13.9727 mL 27.9455 mL 69.8636 mL
5 mM 0.5589 mL 2.7945 mL 5.5891 mL 13.9727 mL
10 mM 0.2795 mL 1.3973 mL 2.7945 mL 6.9864 mL
15 mM 0.1863 mL 0.9315 mL 1.8630 mL 4.6576 mL
20 mM 0.1397 mL 0.6986 mL 1.3973 mL 3.4932 mL
25 mM 0.1118 mL 0.5589 mL 1.1178 mL 2.7945 mL
30 mM 0.0932 mL 0.4658 mL 0.9315 mL 2.3288 mL
40 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7466 mL
50 mM 0.0559 mL 0.2795 mL 0.5589 mL 1.3973 mL
60 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1644 mL
80 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.8733 mL
100 mM 0.0279 mL 0.1397 mL 0.2795 mL 0.6986 mL
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(S)-C33 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-C332066488-39-7Phosphodiesterase (PDE)Central nervous system diseasesDiabetesSelectivityInhibitorinhibitorinhibit

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