S1PR1 modulator 1

Name: S1PR1 modulator 1
Brand: MedChemExpress
SKU: HY-126145
Rating: 4.5 (1 reviews)

Cat. No.: HY-126145 Purity: 99.44%: FAQs
Data Sheet SDS COA Handling Instructions

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S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC₅₀ of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4.

For research use only. We do not sell to patients.

S1PR1 modulator 1 Chemical Structure

CAS No. : 2328109-05-1

Size	Price	Stock	Quantity
1 mg	USD 73	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC₅₀ of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4^[1].

IC₅₀ & Target

pIC50: 7.6 (S1PR1), 6 (S1PR3)^[1]

In Vitro

S1PR1 modulator 1 (Compound 10a; (Z,Z)-10a) is selective at S1PR1 over S1PR3 (pIC₅₀, 6), S1PR2 and S1PR4 (pIC₅₀s, <5)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

408.51

Formula

C₂₃H₂₄N₂O₃S

CAS No.

2328109-05-1

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1N2C(/C(S/C2=N\CCC)=C/C3=CC=C(OC(C)=O)C(C)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (153.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4479 mL	12.2396 mL	24.4792 mL
5 mM	0.4896 mL	2.4479 mL	4.8958 mL
10 mM	0.2448 mL	1.2240 mL	2.4479 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.44%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (255 KB) HNMR (287 KB) RP-HPLC (121 KB)

Handling Instructions (2659 KB)

References

[1]. Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Med Chem Lett. 2019 Feb 14;10(3):341-347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4479 mL	12.2396 mL	24.4792 mL	61.1980 mL
	5 mM	0.4896 mL	2.4479 mL	4.8958 mL	12.2396 mL
	10 mM	0.2448 mL	1.2240 mL	2.4479 mL	6.1198 mL
	15 mM	0.1632 mL	0.8160 mL	1.6319 mL	4.0799 mL
	20 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0599 mL
	25 mM	0.0979 mL	0.4896 mL	0.9792 mL	2.4479 mL
	30 mM	0.0816 mL	0.4080 mL	0.8160 mL	2.0399 mL
	40 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	50 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2240 mL
	60 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0200 mL
	80 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7650 mL
	100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6120 mL