Sancycline hydrochloride  (Synonyms: Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride)

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin^[1][2][3].

Sancycline hydrochloride (400 μM, 24 h) decreases 2 chloroethyl ethyl sulfide (CEES) and nitrogen mustard (NM) induced corneal injuries and inhibits Matrix metalloproteinase (MMP)-9 expression to some degree in the basement membrane zone (BMZ) increased by NM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

450.87

C₂₁H₂₃ClN₂O₇

6625-20-3

Solid

White to off-white

O=C(N)C1=C([C@H]([C@@]([H])([C@]2(C1=O)O)C[C@]3(C(C(C4=C(C=CC=C4C3)O)=O)=C2O)[H])N(C)C)O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li G, et al. A brief overview of classical natural product drug synthesis and bioactivity[J]. Organic Chemistry Frontiers, 2022, 9(2): 517-571.

  [2]. Gordon MK, et al. Doxycycline hydrogels as a potential therapy for ocular vesicant injury[J]. J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19.  [Content Brief]

  [3]. Nikita Shanmugam, et al. Abraham solvation parameter model: determination of experiment-based solute descriptor values for 3,5-dimethoxybenzoic acid based on measured solubility data[J]. Physics and Chemistry of Liquids. 2024. 62: 2: 89-100.