2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2 3CLpro-IN-13

SARS-CoV-2 3CLpro-IN-13 is a potent SARS-CoV-2 3CL protease inhibitor with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-13 shows anti-coronavirus activity.

For research use only. We do not sell to patients.

SARS-CoV-2 3CLpro-IN-13 Chemical Structure

SARS-CoV-2 3CLpro-IN-13 Chemical Structure

CAS No. : 622794-09-6

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Based on 1 publication(s) in Google Scholar

SARS-CoV-2 3CLpro-IN-13 Related Antibodies

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  • Purity & Documentation

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Description

SARS-CoV-2 3CLpro-IN-13 is a potent SARS-CoV-2 3CL protease inhibitor with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-13 shows anti-coronavirus activity[1].

IC50 & Target

IC50: 21 nM (SARS-CoV-2 3CL protease)[1]
In Vitro

SARS-CoV-2 3CLpro-IN-13 (compound 1) shows anti-coronavirus activity with IC50s of 0.016, 0.021, 0.383, 2.00 µM for hCoV-229E (Alpha-CoV) 3CLpro, SARS-CoV-2 (Beta-CoV) 3CLpro, SARS-CoV (Beta-CoV) 3CLpro, MERS-CoV (Beta-CoV) 3CLpro, respectively[1].
SARS-CoV-2 3CLpro-IN-13 (0-300 µM) shows a selectivity profile against human cysteine proteases with IC50s of 1.46, >300, 122 µM for 3CLpro SARS-CoV-2, human calpain 1, Cathepsin L respectively[1].
SARS-CoV-2 3CLpro-IN-13 (0.1-10 µM) shows antiviral activity with IC50 values of 1.06, 1.34 µM for SARS-CoV-2 and human coronavirus 229E, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 3CLpro-IN-13 Related Antibodies
Molecular Weight

328.46

Formula

C16H16N4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC2=NC(CSC(NCC3=CN=CC=C3)=S)=CN12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (15.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0445 mL 15.2226 mL 30.4451 mL
5 mM 0.6089 mL 3.0445 mL 6.0890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0445 mL 15.2226 mL 30.4451 mL 76.1128 mL
5 mM 0.6089 mL 3.0445 mL 6.0890 mL 15.2226 mL
10 mM 0.3045 mL 1.5223 mL 3.0445 mL 7.6113 mL
15 mM 0.2030 mL 1.0148 mL 2.0297 mL 5.0742 mL
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SARS-CoV-2 3CLpro-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 3CLpro-IN-13622794-09-6SARS-CoVSARS coronavirusantiviralanti-coronavirushuman coronavirus 229Ecysteine proteasesInhibitorinhibitorinhibit

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