2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. SC-435

SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .

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SC-435 Chemical Structure

SC-435 Chemical Structure

CAS No. : 289037-67-8

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Description

SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations[1] [2] [3].

IC50 & Target

Bile acid transporter[1]
In Vivo

SC-435 (10 μg/1 g; Oral administration; 5-16 weeks) reduces liver and brain damage due to liver failure in mouse models of chronic liver disease induced by Streptozotocin (HY-13753) and acute liver failure induced by Azoxymethane (HY-111375)[2]. SC-435 (0.03-0.1 g/100 g; Oral administration; 12 weeks) alone or in combination with Simvastatin (HY-17502) reduces LDL cholesterol concentration by altering hepatic cholesterol homeostasis and intravascular lipoprotein processing in guinea pig models of endogenous hypercholesterolemia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753) or Azoxymethane (HY-111375) treated male C57BL/6J mice (25-30 g)[2]
Dosage: 10 μg/1 g, 16 weeks;
10 μg/1 g, 5 days
Administration: Oral administration (p.o.)
Result: Reduced bile acids and ammonia concentrations in the blood and brain.
Alleviated liver and brain damages.
Animal Model: Hartley guinea pigs (250-300 g) with endogenous hypercholesterolemia[3]
Dosage: 0.1 g/100 g SC-435;
0.03 g/100 g SC-435 combined with 0.05 g/100 g Simvastatin (HY-17502)
Administration: Oral administration (p.o.); 12 weeks
Result: Compared to the control group, CETP activity was 34% and 56% lower with SC-435 and the combination of SC-435 and Simvastatin, respectively.
Compared to the control group, Cholesterol 7α-hydroxylase and HMG-CoA reductase activities were increased 2-fold with SC-435 and the combination of SC-435 and Simvastatin, respectively.
Compared to the control group, HMG-CoA reductase mRNA expression was increased 33% with SC-435.
Molecular Weight

722.01

Formula

C37H59N3O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)([O-])=O.O[C@@H]1[C@@](C2=CC=C(C=C2)OCCCC[N+]34CCN(CC4)CC3)([H])C5=CC(N(C)C)=CC=C5S(=O)(CC1(CCCC)CCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (69.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3850 mL 6.9251 mL 13.8502 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3850 mL 6.9251 mL 13.8502 mL 34.6256 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL 6.9251 mL
10 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4626 mL
15 mM 0.0923 mL 0.4617 mL 0.9233 mL 2.3084 mL
20 mM 0.0693 mL 0.3463 mL 0.6925 mL 1.7313 mL
25 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3850 mL
30 mM 0.0462 mL 0.2308 mL 0.4617 mL 1.1542 mL
40 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8656 mL
50 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6925 mL
60 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5771 mL
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SC-435 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-435289037-67-8SC435SC 435Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2Bile acidBACholesterolLiver failure modelInhibitorinhibitorinhibit

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