2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)
  4. SCD1 inhibitor-3

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.

For research use only. We do not sell to patients.

SCD1 inhibitor-3 Chemical Structure

SCD1 inhibitor-3 Chemical Structure

CAS No. : 1282606-48-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 In-stock
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 380 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
100 mg USD 1800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

SCD1 inhibitor-3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

IC50 & Target

SCD1[1]
Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
103 nM
Compound: 17a
Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs
[PMID: 25555732]
In Vivo

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 5 mg/kg
Administration: P.o.; 4 hours
Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model: Lewis rats[1]
Dosage: 2~10 mg/kg
Administration: P.o.; 4 hours
Result: A dose-responsive reduction of plasma triglycerides desaturation index.
Molecular Weight

393.37

Formula

C19H16FN7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NNC(N2C=NN(CC3=CC=C(F)C=C3)C2=O)=C1)NCC4=CC=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (317.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5421 mL 12.7107 mL 25.4214 mL
5 mM 0.5084 mL 2.5421 mL 5.0843 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5421 mL 12.7107 mL 25.4214 mL 63.5534 mL
5 mM 0.5084 mL 2.5421 mL 5.0843 mL 12.7107 mL
10 mM 0.2542 mL 1.2711 mL 2.5421 mL 6.3553 mL
15 mM 0.1695 mL 0.8474 mL 1.6948 mL 4.2369 mL
20 mM 0.1271 mL 0.6355 mL 1.2711 mL 3.1777 mL
25 mM 0.1017 mL 0.5084 mL 1.0169 mL 2.5421 mL
30 mM 0.0847 mL 0.4237 mL 0.8474 mL 2.1184 mL
40 mM 0.0636 mL 0.3178 mL 0.6355 mL 1.5888 mL
50 mM 0.0508 mL 0.2542 mL 0.5084 mL 1.2711 mL
60 mM 0.0424 mL 0.2118 mL 0.4237 mL 1.0592 mL
80 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7944 mL
100 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.6355 mL
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SCD1 inhibitor-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCD1 inhibitor-31282606-48-7Stearoyl-CoA Desaturase (SCD)DiabetesDyslipidemiaSkinAcneCancerSafePotentOralInhibitorinhibitorinhibit

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