1. Signaling Pathways
  2. Apoptosis
  3. Caspase

Caspase

Caspase

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16658B
    Z-VAD-FMK
    Inhibitor 99.78%
    Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM.
    Z-VAD-FMK
  • HY-12305
    Q-VD-OPh
    Inhibitor 99.92%
    Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.
    Q-VD-OPh
  • HY-13755
    Sulforaphane
    Inhibitor 99.75%
    Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties.
    Sulforaphane
  • HY-16658
    Z-VAD(OMe)-FMK
    Inhibitor 98.20%
    Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.
    Z-VAD(OMe)-FMK
  • HY-13205
    Belnacasan
    Inhibitor 99.99%
    Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.
    Belnacasan
  • HY-171006
    IRF1-IN-1
    Inhibitor 99.72%
    IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury.
    IRF1-IN-1
  • HY-171007
    IRF1-IN-2
    Inhibitor 99.83%
    IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury.
    IRF1-IN-2
  • HY-155612A
    (Rac)-M826
    Inhibitor 99.75%
    (Rac)-M826 is the racemate of M826 (HY-155612). M826 is a selective and reversible inhibitor for caspase-3 with an IC50 of 0.005 μM. M826 inhibits apoptosis in cell NT2. M826 can be used for nervous system diseases research.
    (Rac)-M826
  • HY-12466
    Z-DEVD-FMK
    Inhibitor ≥98.0%
    Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM.
    Z-DEVD-FMK
  • HY-19696
    Tauroursodeoxycholate
    Inhibitor 99.93%
    Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate
  • HY-10396
    Emricasan
    Inhibitor 99.59%
    Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.
    Emricasan
  • HY-14654
    Aspirin
    Activator 99.90%
    Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin
  • HY-B1081A
    Oxidopamine hydrobromide
    Activator 99.95%
    Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
    Oxidopamine hydrobromide
  • HY-16990
    Ac-YVAD-cmk
    Inhibitor 98.94%
    Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
    Ac-YVAD-cmk
  • HY-101297
    Z-IETD-FMK
    Inhibitor ≥98.0%
    Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor.
    Z-IETD-FMK
  • HY-B1081
    Oxidopamine hydrochloride
    Activator 99.91%
    Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
    Oxidopamine hydrochloride
  • HY-13594
    Chlorin e6
    98.38%
    Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.
    Chlorin e6
  • HY-121320
    Raptinal
    Activator ≥98.0%
    Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9.
    Raptinal
  • HY-N2334
    Glycochenodeoxycholic acid
    Inhibitor 99.25%
    Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
    Glycochenodeoxycholic acid
  • HY-N2027
    Taurochenodeoxycholic acid
    99.86%
    Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
    Taurochenodeoxycholic acid
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity

Upon binding to their cognate ligand, death receptors such as Fas and TRAILR can activate initiator Caspases (Pro-caspase 8 and Pro-caspase 10) through dimerization mediated by adaptor proteins such as FADD and TRADD. Active Caspase 8 and Caspase 10 then cleave and activate the effector Caspase 3, 6 and 7, leading to apoptosis. ROS/DNA damage and ER stress trigger Caspase 2 activation. Active Caspase 2 cleaves and activates Caspase 3 and initiates apoptosis directly. Caspase 2, 8 and 10 can also cleave Bid, stimulate mitochondrial outer membrane permeabilization (MOMP) and initiate the intrinsic apoptotic pathway. Following MOMP, mitochondrial intermembrane space proteins such as Smac and Cytochrome C are released into the cytosol. Cytochrome C interacts with Apaf-1, triggering apoptosome assembly, which activates Caspase 9. Active Caspase 9, in turn, activates Caspase 3, 6 and 7, leading to apoptosis. Mitochondrial release of Smac facilitates apoptosis by blocking the inhibitor of apoptosis (IAP) proteins. 

 

Following the binding of TNF to TNFR1, TNFR1 binds to TRADD, which recruits RIPK1, TRAF2/5 and cIAP1/2 to form TNFR1 signaling complex I. Formation of the complex IIa and complex IIb is initiated either by RIPK1 deubiquitylation mediated by CYLD or by RIPK1 non-ubiquitylation due to depletion of cIAPs. The Pro-caspase 8 homodimer in complex IIa and complex IIb generates active Caspase 8. This active Caspase 8 in the cytosol then carries out cleavage reactions to activate downstream executioner caspases and thus induce classical apoptosis[1][2]

 

Reference:

[1]. Thomas C, et al. Caspases in retinal ganglion cell death and axon regeneration. Cell Death Discovery volume 3, Article number: 17032 (2017).
[2]. Brenner D, et al. Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol. 2015 Jun;15(6):362-74.

Caspase 1

Caspase 2

Caspase 3

Caspase 4

Caspase 5

Caspase 6

Caspase 7

Caspase 8

Caspase 9

Caspase 10

Caspase 12

Caspase

Caspase 11

Caspase-13

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Caspase Inducers, Substrates, Inhibitors, Agonists, Activators, Modulators & Chemicals
Product NameCaspase 1Caspase 2Caspase 3Caspase 4Caspase 5Caspase 6Caspase 7Caspase 8Caspase 9Caspase 10Caspase 12CaspaseCaspase 11Caspase-13Purity    
Z-VAD-FMK           
Caspase
  99.78%
Q-VD-OPh
Caspase-1, IC50: 25-400 nM
 
Caspase-3, IC50: 25-400 nM
   
Caspase-7, IC50: 48 nM
Caspase-8, IC50: 25-400 nM
Caspase-9, IC50: 25-400 nM
Caspase-10, IC50: 25-400 nM
Caspase-12, IC50: 25-400 nM
   99.92%
Sulforaphane  
Caspase-3
           99.75%
Z-VAD(OMe)-FMK           
Caspase
  98.20%
Belnacasan
Caspase-1
             99.99%
IRF1-IN-1
Caspase-1
             99.72%
IRF1-IN-2
Caspase-1
             99.83%
(Rac)-M826  
Caspase 3, IC50: 0.005 μM
           99.75%
Z-DEVD-FMK  
Caspase-3, IC50: 18 μM
           ≥98.0%
Tauroursodeoxycholate  
Caspase-3
       
Caspase-12
   99.93%
Emricasan           
Caspase
  99.59%
Oxidopamine hydrobromide  
Caspase-3
    
Caspase-8
Caspase-9
     99.95%
Ac-YVAD-cmk
Caspase-1
             98.94%
Z-IETD-FMK       
Caspase-8
      ≥98.0%
Oxidopamine hydrochloride  
Caspase-3
    
Caspase-8
Caspase-9
     99.91%
Chlorin e6  
Caspase 3
           98.38%
Raptinal  
Caspase 3
           ≥98.0%
Tauroursodeoxycholate sodium  
Caspase-3
       
Caspase-12
   98.40%
Ac-DEVD-CHO
Caspase-1, Ki: 18 nM
Caspase-2, Ki: 1710 nM
Caspase 3, Ki: 0.23 nM
Caspase-4, Ki: 132 nM
Caspase-5, Ki: 205 nM
Caspase-6, Ki: 31 nM
Caspase-7, Ki: 1.6 nM
Caspase-8, Ki: 0.92 nM
Caspase-9, Ki: 60 nM
Caspase-10, Ki: 12 nM
    99.55%
Guggulsterone           
Caspase
  99.95%
Benzbromarone  
Caspase 3
    
Caspase-8
Caspase 9
     99.81%
Wedelolactone            
Caspase-11
 99.91%
Fucoxanthin  
Caspase 3
    
Caspase-8
Caspase 9
     98.99%
Ginsenoside Rh2       
Caspase-8
Caspase-9
     98.87%
Digitoxin  
Caspase 3
     
Caspase-9
     99.36%
PAC-1  
Procaspase-3, EC50: 2.08 μM
           99.93%
N1,N11-Diethylnorspermine tetrahydrochloride  
Caspase 3
           ≥98.0%
Probucol  
Caspase 3
     
Caspase 9
     99.97%
Terfenadine 
Caspase-2
 
Caspase-4
    
Caspase-9
     99.91%
RGD peptide (GRGDNP)  
Caspase 3
           99.79%
Dehydrocorydaline      
Caspase-7
Caspase-8
      99.77%
BOC-D-FMK           
Caspase
  
Ac-FLTD-CMK
Caspase-1, IC50: 46.7 nM
  
Caspase-4, IC50: 1.49 μM
Caspase-5, IC50: 329 nM
         99.53%
VRT-043198
Caspase-1, Ki: 0.8 nM
  
Caspase-4, Ki: 0.6 nM
          98.89%
Denosumab  
Caspase 3
           99.10%
Z-LEHD-FMK        
Caspase-9
     98.09%
Dihydrocapsaicin  
Caspase 3
           99.93%
(±)-Naringenin        
Caspase 9
     98.88%
Z-YVAD-FMK           
Caspase
  ≥98.0%
Citicoline  
Caspase 3
    
Caspase-8
Caspase-9
     99.87%
Elevenostat  
Caspase-3
           
Dynorphin A  
Caspase 3
           98.06%
Z-VDVAD-FMK 
Caspase-2
            ≥98.0%
Hydralazine hydrochloride  
Caspase 3
    
Caspase-8
Caspase-9
     99.97%
Z-FA-FMK 
Caspase-2
Caspase-3
  
Caspase-6
Caspase-7
       99.14%
Tryptophol       
Caspase-8
      99.96%
BV02  
Caspase-3
           99.75%
AVN-944  
Caspase 3
    
Caspase 8
Caspase 9
     99.77%
Peiminine  
Caspase 3
    
Caspase-8
Caspase-9
     99.94%
Azadirachtin  
Caspase 3
           99.06%
L67
Caspase-1
             ≥98.0%
Deltamethrin  
Caspase 3
           99.93%
Z-LEVD-FMK   
Caspase-4
          ≥98.0%
Triclabendazole  
Caspase 3
    
Caspase-8
Caspase-9
     98.72%
Paris saponin VII  
Caspase-3
     
Caspase-9
     99.96%
Asperosaponin VI  
Caspase 3
           98.91%
N-Acetyl-L-methionine  
Caspase-3
           99.46%
Angelicin  
Caspase-3
     
Caspase-9
     99.98%
8-Gingerol        
Caspase-9
     99.82%
Cystamine  
Caspase 3, IC50: 23.6 μM
           ≥98.0%
Cystamine dihydrochloride  
Caspase 3, IC50: 23.6 μM
           ≥98.0%
Ossirene
Caspase-1
             ≥98.0%
Almorexant  
Caspase-3
           99.46%
Zerumbone  
Caspase 3
           99.87%
(R)-Sulforaphane  
Procaspase-3
           99.48%
TC11        
Caspase-9
     99.55%
MX1013           
Caspase
  ≥99.0%
Ac-YVAD-CHO
Caspase-1
             98.23%
Thiabendazole  
Caspase 3
     
Caspase-9
     99.77%
Dracorhodin perchlorate  
Caspase 3
           99.14%
Caspase-9 Inhibitor III        
Caspase-9
     99.00%
Ac-DEVD-pNA  
Caspase-3
   
Caspase-7
       98.12%
Z-WEHD-FMK
Caspase-1
             ≥98.0%
2-HBA  
Caspase-3
      
Caspase-10
    99.09%
N-Acetyl-L-tryptophan
Caspase-1
             99.38%
δ-Secretase inhibitor 11  
Caspase-3, IC50: 31.86 ± 1. μM
    
Caspase-8, IC50: 86.71 ± 10 μM
      99.06%
L6H21  
Caspase 3
           99.46%
Ac-WEHD-AFC TFA
Caspase-1
             99.01%
Citicoline sodium  
Caspase 3
    
Caspase-8
Caspase-9
     99.90%
Pralnacasan
Interleukin-1β converting enzyme, Ki: 1.4 nM
             99.83%
Trifloxystrobin  
Caspase 3
    
Caspase-8
Caspase-9
     99.49%
CZL55
Caspase-1, IC50: 24 nM
             98.92%
Biotin-VAD-FMK           
Caspase
  ≥98.0%
Boc-Asp(OMe)-fluoromethyl ketone           
Caspase
  ≥98.0%
Ac-YVAD-pNA
Caspase-1
             99.93%
5,​7,​4'-​Trimethoxyflavone  
Caspase-3
           99.65%
Fenbufen
Caspase-1, IC50: 4.4 μM
 
Caspase-3, IC50: 1.2 μM
Caspase-4, IC50: 0.57 μM
Caspase-5, IC50: 0.87 μM
   
Caspase-9, IC50: 0.76 μM
     99.33%
Arnicolide D           
Caspase
  99.69%
Almorexant hydrochloride  
Caspase-3
           99.98%
Chelidonic acid
Caspase-1
             99.91%
5,7-Dihydroxychromone  
Caspase-3
     
Caspase-9
     99.94%
MPT0B392           
Caspase
  99.63%
PETCM  
Caspase 3
           99.68%
MMPSI  
human Caspase-3, IC50: 1.7 μM
           99.97%
API-1  
Caspase 3
    
Caspase-8
Caspase-9
     99.62%
Caspase-3-IN-1
Caspase-1, IC50: >10000 nM
 
Caspase-3, IC50: 14.5 ± 1.6 nM
  
Caspase-6, IC50: >5000 nM
Caspase-7, IC50: 21.8 ± 3.5 nM
Caspase-8, IC50: >50000 nM
      
cRIPGBM chloride
Caspase-1
             99.73%
14-Deoxyandrographolide  
Caspase 3
           99.47%
Magnesium isoglycyrrhizinate hydrate
Caspase-1
             99.81%
ASP3026  
Caspase-3
           99.88%
Mca-YVADAP-Lys(Dnp)-OH TFA
Caspase-1
             99.45%
Aspidin BB  
Caspase-3
           98.08%
AC-VEID-CHO TFA  
Caspase 3, IC50: 13.6 nM
  
Caspase-6, IC50: 16.2 nM
Caspase-7, IC50: 162.1 nM
       98.7%
Heptelidic acid  
Caspase-3
           
Thevetiaflavone  
Caspase-3
           ≥98.0%
Sanggenon G  
Caspase-3
    
Caspase-8
Caspase-9
     
ML132
Caspase-1, IC50: 34.9 nM
  
Caspase-4, IC50: 1.27 μM
Caspase-5, IC50: 0.85 μM
  
Caspase-8, IC50: 4.18 μM
Caspase-9, IC50: 2.85 μM
     98.75%
Procaspase-3/6 activator 1  
Procaspase-3, EC50: 2.4 ± 0.2 μM
  
Procaspase-6, EC50: 2.8 ± 0.3 μM
        98.97%
Destruxin B  
Caspase-3
           99.86%
Nivalenol           
Caspase
  99.24%
Ginsenoside Rh4  
Caspase 3
    
Caspase 8
Caspase 9
     99.28%
CASP8-IN-1       
Caspase 8, IC50: 0.7 μM
      98.97%
CZL80
Caspase-1, IC50: 0.01 μM
             98.31%
M190S  
Caspase 3, EC50: 23.4 nM
           99.84%
Ivachtin  
Caspase-3, IC50: 23 nM
           99.71%
EP1013           
Caspase
  
TD1092  
Caspase 3
   
Caspase-7
       99.49%
PARP-1-IN-2  
Caspase-3
     
Caspase-9
     99.48%
p-nitro-Pifithrin-α  
Caspase-3
           
Akt1/Akt2-IN-2  
Caspase-3
           98.57%
PAWI-2  
Caspase 3
   
Caspase-7
       99.29%
BBR-BODIPY        
Caspase-9
     98.15%
Ac-Tyr-Val-Lys-Asp-aldehyde
Caspase-1
             99.89%
Dehydrotrametenolic acid  
Caspase-3
           99.95%
KEA1-97  
Caspase 3, IC50: 10 μM
           98.05%
Anticancer agent 43  
Caspase 3
           98.58%
Ac-VDVAD-CHO TFA 
Caspase-2, IC50: 46 nM
Caspase-3, IC50: 15 nM
           99.15%
Citicoline-d9 sodium  
Caspase 3
    
Caspase-8
Caspase-9
     99.81%
Duocarmycin A  
Procaspase-3
     
Caspase-9
     
BAG3/HSP70-IN-1  
Caspase 3
     
Caspase-9
     
cRIPGBM
Caspase-1
             
Ac-LDESD-AMC 
Caspase-2
            
Z-LEED-FMK
Caspase-1
  
Caspase-4
         
Caspase-13
15-Acetoxyscirpenol           
Caspase
  99.35%
Ganoderic acid T1  
Caspase 3
     
Caspase-9
     
Mca-DEVDAP-K(Dnp)-OH  
Caspase-3
           
Cimiside E  
Caspase 3
           
MAPK-IN-3      
Caspase-7
 
Caspase 9
     
IETD-CHO       
Caspase-8
      
Caspase-3 activator 3  
Caspase 3
           
Ac-WEHD-AFC
Caspase-1
             
FMP  
Caspase 3
    
Caspase 8
      
WF-210  
Procaspase-3, IC50: 0.95 μM
           
Microtubule destabilizing agent-2  
Caspase 3
           
TRP-601 
Caspase-2
Caspase 3
           
Caspase-3/7 activator 2  
Caspase-3
   
Caspase-7
       
BRD4 Inhibitor-15  
Caspase-3
Procaspase-3
           
EMT inhibitor-3  
Caspase 3
     
Caspase 9
     
Apoptotic agent-2  
Caspase 3
           
N1,N11-Diethylnorspermine  
Caspase 3
           
Caspase-3/7 activator 1  
Caspase-3
   
Caspase-7
       
PROTAC BRD4 Degrader-6  
Caspase 3
           
Caspase-3 activator 4  
Caspase 3
           
KDM1/CDK1-IN-1  
Caspase-3
           
Z-LEHD-FMK TFA        
Caspase-9
     
LSD1-IN-26  
Caspase-3
     
Caspase-9
     
Ac-DMQD-AMC  
Caspase 3
           
Anticancer agent 64  
Caspase 3
   
Caspase-7
       
Ac-AAVALLPAVLLALLAP-DEVD-CHO  
Caspase 3
           
Akt/mTOR-IN-1  
Caspase 3
           
Ac-AAVALLPAVLLALLAP-LEVD-CHO   
Caspase-4
          
Z-ATAD-FMK        
Caspase-9
     
Bcl-2-IN-6      
Caspase-7
       
Dynorphin A TFA  
Caspase-3
           
C105SR  
Caspase 3
   
Caspase-7
       99.49%
Citicoline (Standard)  
Caspase 3
    
Caspase-8
Caspase-9
     
14-Deoxyandrographolide (Standard)  
Caspase 3
           
M867  
Caspase 3
           
Bcl-2-IN-7      
Caspase-7
       
Anticancer agent 201  
Caspase-3
           
Astin B  
Caspase-3
     
Caspase-9
     
EGFR-IN-109  
Caspase-3
     
Caspase-9
     
CDK1/2/4-IN-1  
Caspase 3
           
VEGFR-2-IN-40  
Caspase 3
           
LM-021
Caspase-1
             
Apoptotic agent-3  
Caspase 3
           
EGFR-IN-134  
Caspase 3
    
Caspase 8
Caspase 9
     
Lycopodine  
Caspase-3
           
Citicoline (sodium) (Standard)  
Caspase 3
    
Caspase-8
Caspase-9
     
Ac-LEVD-CHO   
Caspase-4
          
Ginsenoside Rh2 (Standard)       
Caspase-8
Caspase-9
     
PARP1-IN-17  
Caspase 3
           
EM20-25        
Caspase 9
     
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone  
Caspase 3
           
Mca-YVADAP-Lys(Dnp)-OH
Caspase-1
             
Topo I/II-IN-2  
Caspase 3
     
Caspase 9
     
28-Deoxonimbolide  
Caspase-3
    
Caspase-8
Caspase-9
     
Apoptosis inducer 19  
Caspase 3
           
Caspase-3/7 activator 3  
Caspase-3
   
Caspase-7
       
Ac-YVAD-CHO acetate
Caspase-1
             
Ac-DEVD-CMK  
Caspase-3
           
Anticancer agent 63  
Caspase-3
           
KTt-45  
Caspase 3
     
Caspase-9
     
Ac-VDVAD-CHO 
Caspase-2, IC50: 46 nM
Caspase-3, IC50: 15 nM
           
Ac-Trp-Glu-His-Asp-Aldehyde
Caspase-1, Ki: 56 pM
             
Ganoderic acid Mk  
Caspase-3
     
Caspase-9
     
Ac-AAVALLPAVLLALLAP-YVAD-CHO
Caspase-1
             
Apoptosis inducer 30      
Caspase-7
 
Caspase-9
     
VEGFR-2/AKT-IN-2  
Caspase 3
           
AC-VEID-CHO  
Caspase 3, IC50: 13.6 nM
  
Caspase-6, IC50: 16.2 nM
Caspase-7, IC50: 162.1 nM
       
Patuletin  
Caspase 3
           
Mofarotene  
Caspase 3
     
Caspase-9
     
HDAC-IN-82  
Caspase 3
   
Caspase-7
       
Myrothecine A  
Caspase 3
 
Caspase-5
  
Caspase-8
      
AD-2646  
Caspase 3
    
Caspase-8
Caspase-9
     
N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride  
Caspase-3, IC50: 12.0 μM
  
Caspase-6, IC50: 54.5 μM
Caspase-7, IC50: 19.3 μM