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STS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (4) Autophagy (3) Bacterial (1) Endogenous Metabolite (3) Estrogen Receptor/ERR (3) Fungal (1) Isotope-Labeled Compounds (5) JAK (1) MNK (1) PKA (1) PKC (2) Progesterone Receptor (7) Small Interfering RNA (siRNA) (1) Steroid Sulfatase (11)
By Research Areas:	Cancer (17) Endocrinology (8) Infection (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15141

Staurosporine Maximum Cited Publications 130 Publications Verification Antibiotic AM-2282; STS; AM-2282	PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-B0084

Dienogest 1 Publications Verification STS 557	Progesterone Receptor	Endocrinology
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-W062700

STS-E412	JAK	Neurological Disease
STS-E412 is a selective activator of tissue-protective EPO receptor (including EPOR and CD131). STS-E412 can be used for research of neurodegenerative diseases and organ protection .

HY-B0084S2

Dienogest-d6 STS 557-d₆	Isotope-Labeled Compounds Progesterone Receptor Autophagy Apoptosis	Endocrinology Cancer
Dienogest-d₆ is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis .

HY-15141G

Staurosporine Antibiotic AM-2282; STS; AM-2282	PKC	Infection Cancer
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-RS13969

STS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STS Human Pre-designed siRNA Set A contains three designed siRNAs for STS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STS Human Pre-designed siRNA Set A STS Human Pre-designed siRNA Set A

HY-B0084S4

Dienogest-13C,15N,d4 STS 557-¹³C,¹⁵N,d₄	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-B0084S3

Dienogest-13C2,15N STS 557-¹³C₂,¹⁵N	Progesterone Receptor Isotope-Labeled Compounds	Endocrinology
Dienogest- ¹³C₂, ¹⁵N (STS 557- ¹³C₂, ¹⁵N) is ¹³C- and ¹⁵N-labeled Dienogest (HY-B0084) .

HY-B0084S

Dienogest-d4 STS 557-d₄	Isotope-Labeled Compounds Progesterone Receptor Autophagy Apoptosis	Endocrinology Cancer
Dienogest-d₄ is deuterium labeled Dienogest.

HY-B0084S1

Dienogest-d5 STS 557-d₅	Isotope-Labeled Compounds Progesterone Receptor Autophagy Apoptosis	Endocrinology Cancer
Dienogest-d₅ is deuterium labeled Dienogest.

HY-155235

Steroid sulfatase-IN-7	Steroid Sulfatase	Cancer
Steroid sulfatase-IN-7 is an irreversible steroid sulfatase (STS) inhibitor with an IC₅₀ value of 0.05 nM against human placental STS and can be used in cancer research .

HY-156902

Steroid sulfatase-IN-8	Steroid Sulfatase	Others
Steroid sulfatase-IN-8 (7) is a *STS* inhibitor with PM IC₅₀ value of 1 nM, JEG-3 IC₅₀ of 0.025 nM, respecively .

HY-155234

Steroid sulfatase-IN-6	Steroid Sulfatase	Cancer
Steroid sulfatase-IN-6 (Compound 10c) is an irreversible inhibitor of steroid sulfatase (STS). Steroid sulfatase-IN-6 has an K_i value of 0.4 nM for human placenta STS. Steroid sulfatase-IN-6 can be used for tumor diseases research .

HY-150542

Steroid sulfatase-IN-2	Steroid Sulfatase	Cancer
Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC₅₀ value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer .

HY-151201

Steroid sulfatase/17β-HSD1-IN-3	Steroid Sulfatase	Cancer
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC₅₀ value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .

HY-151202

Steroid sulfatase/17β-HSD1-IN-4	Steroid Sulfatase	Cancer
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC₅₀ value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .

HY-151200

Steroid sulfatase-IN-4	Steroid Sulfatase	Endocrinology
Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC₅₀ of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis .

HY-14585

Estrone O-sulfamate Estrone 3-O-sulfamate	Steroid Sulfatase	Cancer
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC₅₀ values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer .

HY-B0084R

Dienogest (Standard)	Progesterone Receptor	Endocrinology
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-113293B

Estrone sulfate sodium 1 Publications Verification	Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). Estrone sulfate can be used for the research of breast cancer .

HY-150543

Steroid sulfatase-IN-3	Steroid Sulfatase	Cancer
Steroid sulfatase-IN-3 (compound 1q) is a potent *STS* (Steroid sulfatase) inhibitor, with an IC₅₀ of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC₅₀ of 1.04 µM .

HY-113293BS

Estrone sulfate-d5 sodium	Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estrone sulfate-d₅ (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

HY-113293BS1

Estrone sulfate-d4 sodium	Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estrone sulfate-d₄ (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

HY-155233

Steroid sulfatase-IN-5	Steroid Sulfatase	Cancer
Steroid sulfatase-IN-5 (compound 10b) is a steroid sulfatase (STS) inhibitor (IC₅₀: 0.32 nM). Steroid sulfatase-IN-5 inhibits T-47D cell proliferation with an IC₅₀ of 35.7 μM. Steroid sulfatase-IN-5 can be used for research of breast cancer .

HY-156511

ETC-168	MNK	Cancer
ETC-168 is a selective and oral active MNK inhibitor with the IC₅₀ values of 23 and 43 nM against MNK1 and MNK2, respectively. ETC-168 shows antiproliferative efficacy in vivo and in vitro .

HY-155010

Steroid sulfatase/17β-HSD1-IN-5	Steroid Sulfatase	Metabolic Disease
Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC₅₀s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .

Cat. No.	Product Name	Type

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Fluorescent Dye
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

Cat. No.	Product Name	Type

HY-15141G

Staurosporine (GMP) Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Biochemical Assay Reagents
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15141

Staurosporine 125+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Source classification Marine microorganism Disease Research Fields Indole Alkaloids	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-113293B

Estrone sulfate sodium 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). Estrone sulfate can be used for the research of breast cancer .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74484

	*UBASH3B/STS1 Protein, Human (His)* Ubiquitin-associated and SH3 domain-containing protein B; STS-1; TULA-2; UBASH3B	Human	E. coli
	UBASH3B/STS1 protein blocks CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases, leading to the accumulation of activating receptors such as T cell receptors and EGFR on the cell surface. It exhibits tyrosine phosphatase activity against substrates such as EGFR, FAK, SYK and ZAP70. UBASH3B/STS1 Protein, Human (His) is the recombinant human-derived UBASH3B/STS1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of UBASH3B/STS1 Protein, Human (His) is 268 a.a., with molecular weight of ~30 kDa.

HY-P76687

	UBASH3A Protein, Human (His) 1 Publications Verification Ubiquitin-associated and SH3 domain-containing protein A; CLIP4; STS-2; TULA-1	Human	E. coli
	UBASH3A interferes with CBL-mediated downregulation and degradation of receptor-type tyrosine kinases and promotes the accumulation of activating receptors such as T cell receptors, EGFR and PDGFRB on the cell surface. It exhibits minimal protein tyrosine phosphatase activity and may act as a dominant negative regulator of UBASH3B-dependent dephosphorylation. UBASH3A Protein, Human (His) is the recombinant human-derived UBASH3A protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0084S2

Dienogest-d6
Dienogest-d₆ is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis .

HY-113293BS1

Estrone sulfate-d4 sodium
Estrone sulfate-d₄ (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

HY-B0084S4

Dienogest-13C,15N,d4
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-B0084S3

Dienogest-13C2,15N
Dienogest- ¹³C₂, ¹⁵N (STS 557- ¹³C₂, ¹⁵N) is ¹³C- and ¹⁵N-labeled Dienogest (HY-B0084) .

HY-B0084S

Dienogest-d4
Dienogest-d₄ is deuterium labeled Dienogest.

HY-B0084S1

Dienogest-d5
Dienogest-d₅ is deuterium labeled Dienogest.

HY-113293BS

Estrone sulfate-d5 sodium
Estrone sulfate-d₅ (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

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STS

Inhibitors & Agonists

Fluorescent Dye

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