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Results for "

26-L5

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

3

Biochemical Assay Reagents

2

Natural
Products

1

Click Chemistry

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-R00497
    hsa-miR-26b-5p mimic

    		MicroRNA Cancer
    hsa-miR-26b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-26b-5p mimic
    hsa-miR-26b-5p mimic
  • HY-N1622
    1-Dehydroxy-23-deoxojessic acid

    		Others Cancer
    1-Dehydroxy-23-deoxojessic acid (compound 10) is a cycloartane-type triterpene. 1-Dehydroxy-23-deoxojessic acid exhibits cytotoxicity against murine colon 26-L5 carcinoma cells, with an EC50 of 62.38 μM .
    1-Dehydroxy-23-deoxojessic acid
  • HY-N0998
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one

    		Others Cancer
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders .
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
  • HY-N8398
    n-Octyl caffeate

    		Apoptosis Cancer
    n-Octyl caffeate shows anti-cancer and apoptosis inducing activity in highly liver-metastatic murine colon 26-L5 carcinoma cell lines .
    n-Octyl caffeate
  • HY-N10158
    1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

    		Others Cancer
    1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells .
    1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
  • HY-122980
    Myxochelin A

    (S)-Myxochelin A

    		 Others Infection
    Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.
    Myxochelin A
  • HY-R00495
    hsa-miR-26a-5p mimic

    		MicroRNA Cancer
    hsa-miR-26a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-26a-5p mimic
    hsa-miR-26a-5p mimic
  • HY-RS13139
    SLC26A5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SLC26A5 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC26A5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SLC26A5 Human Pre-designed siRNA Set A
    SLC26A5 Human Pre-designed siRNA Set A
  • HY-RI00495
    hsa-miR-26a-5p inhibitor

    		MicroRNA Cancer
    hsa-miR-26a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-26a-5p inhibitor
    hsa-miR-26a-5p inhibitor
  • HY-RI00497
    hsa-miR-26b-5p inhibitor

    		MicroRNA Cancer
    hsa-miR-26b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-26b-5p inhibitor
    hsa-miR-26b-5p inhibitor
  • HY-R00495A
    hsa-miR-26a-5p agomir

    		MicroRNA Cancer
    hsa-miR-26a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-26a-5p agomir
    hsa-miR-26a-5p agomir
  • HY-R00497A
    hsa-miR-26b-5p agomir

    		MicroRNA Cancer
    hsa-miR-26b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-26b-5p agomir
    hsa-miR-26b-5p agomir
  • HY-W002688
    2,6-Dichloro-5-fluoronicotinic acid

    		Biochemical Assay Reagents Others
    2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,6-Dichloro-5-fluoronicotinic acid
  • HY-N8767
    Methyl 2-(6-acetyl-5-hydroxy-2,3-dihydrobenzofuran-2-yl)propenoate

    		Others Others
    Methyl 2-(6-acetyl-5-hydroxy-2,3-dihydrobenzofuran-2-yl)propenoate is a Phenols product that can be isolated from the herbs of Vernonia cinerea .
    Methyl 2-(6-acetyl-5-hydroxy-2,3-dihydrobenzofuran-2-yl)propenoate
  • HY-RI00495A
    hsa-miR-26a-5p antagomir

    		MicroRNA Cancer
    hsa-miR-26a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-26a-5p antagomir
    hsa-miR-26a-5p antagomir
  • HY-RI00497A
    hsa-miR-26b-5p antagomir

    		MicroRNA Cancer
    hsa-miR-26b-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-26b-5p antagomir
    hsa-miR-26b-5p antagomir
  • HY-120329
    Lu 26-046

    		mAChR Others
    Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with Ki of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .
    Lu 26-046
  • HY-W145609
    Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP

    		Biochemical Assay Reagents Others
    Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP
  • HY-136638
    ML328

    		Bacterial Infection
    ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .
    ML328
  • HY-146230
    VEGFR-2-IN-26

    		VEGFR Cancer
    VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells .
    VEGFR-2-IN-26
  • HY-166965
    Neu5Gc(α2,6)N-Acetylgalactosamine

    		Biochemical Assay Reagents Others
    Neu5Gc(α2,6)N-Acetylgalactosamine is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
    Neu5Gc(α2,6)N-Acetylgalactosamine
  • HY-15424
    5-Iodotubercidin
    5+ Cited Publications

    NSC 113939; 5-ITu

    		 Adenosine Kinase Cancer
    5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .
    5-Iodotubercidin
  • HY-144712
    L5-DA

    		G-quadruplex Apoptosis Cancer
    L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .
    L5-DA
  • HY-146584
    Cathepsin C-IN-5

    		Cathepsin Inflammation/Immunology
    Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .
    Cathepsin C-IN-5

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