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5α-reductase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (21) Androgen Receptor (2) Apoptosis (4) Bacterial (2) Endogenous Metabolite (5) Isotope-Labeled Compounds (2)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Endocrinology (5) Infection (1) Inflammation/Immunology (4) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Glutathione Reductase Aldose Reductase 5 alpha Reductase Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) TrxR GSNOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is a potent and competitive *5α-reductase* inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-U00376

5α-reductase-IN-1	5 alpha Reductase	Metabolic Disease
5α-reductase-IN-1 is an inhibitor of *5α-reductase*, used for the research of patterned alopecia in combination with minoxidil.

HY-118091A

Bexlosteride LY300502	Others	Cancer
Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive *5α-reductase* inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-103245

Cl-4AS-1	Androgen Receptor	Cancer
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC₅₀ = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively) .

HY-152094

SRD5A1-IN-1	Others	Endocrinology
SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC₅₀ of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression .

HY-13635S

Finasteride-d9 MK-906-d₉	Isotope-Labeled Compounds 5 alpha Reductase	Cancer
Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-13635R

Finasteride (Standard) MK-906 (Standard)	5 alpha Reductase	Cancer
Finasteride (Standard) is the analytical standard of Finasteride. This product is intended for research and analytical applications. Finasteride (MK-906) is a potent and competitive *5α-reductase* inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-118091

LY191704	5 alpha Reductase	Endocrinology
LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selective human type I 5α-reductase inhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by 5α-reductase type 1 .

HY-118091B

LY300503	Others	Others
LY300503 is an enantiomer of LY191704. LY191704 is a human type I 5α-reductase inhibitor .

HY-106174

Lapisteride CS 891	5 alpha Reductase	Cancer
Lapisteride (CS 891) is an orally active 5α-reductase inhibitor. Lapisteride can be used in cancer research .

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	5 alpha Reductase Endogenous Metabolite Bacterial	Inflammation/Immunology
Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-106951

MK 386 L-733692	5 alpha Reductase	Cancer
MK 386 (L-733692) is a selective 5-α-reductase I inhibitor, used for prostate cancer inhibition .

HY-106129

Izonsteride LY 320236	5 alpha Reductase	Endocrinology Cancer
Izonsteride (Compound LY320236) is an inhibitor of *5α-reductase* (IC₅₀ = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity .

HY-139349

Finasteride carboxaldehyde	Endogenous Metabolite	Others
Finasteride carboxaldehyde (Compound M2) is the metabolite of 5α-reductase inhibitor Finasteride (HY-13635) in human bile and urine .

HY-133949

8,11-Eicosadiynoic acid	5 alpha Reductase	Endocrinology
8,11-Eicosadiynoic acid, an unsaturated fatty acid, is a steroid 5α-reductase inhibitor. 8,11-Eicosadiynoic acid can be used for the research of acne .

HY-N1200

Stigmasterol glucoside	5 alpha Reductase	Inflammation/Immunology
Stigmasterol glucoside is a sterol isolated from P. urinaria with high antioxidant and anti-inflammatory activities , act as an inhibitor of *5α-reductase* with an IC₅₀ of 27.2 µM .

HY-13613

Dutasteride 2 Publications Verification GG 745; GI 198745	5 alpha Reductase Apoptosis	Cancer
Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-B0141AS

Alpha-Estradiol-d3 Alfatradiol-d₃; Epiestradiol-d₃; Epiestrol-d₃	5 alpha Reductase Endogenous Metabolite	Inflammation/Immunology
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-B0141AS1

Alpha-Estradiol-d2 Alfatradiol-d₂; Epiestradiol-d₂; Epiestrol-d₂	5 alpha Reductase Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].

HY-B0141AR

Alpha-Estradiol (Standard) Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)	5 alpha Reductase Endogenous Metabolite Bacterial	Inflammation/Immunology
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-13613R

Dutasteride (Standard) GG 745 (Standard); GI 198745 (Standard)	5 alpha Reductase Apoptosis	Cancer
Dutasteride (Standard) is the analytical standard of Dutasteride. This product is intended for research and analytical applications. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-13613S

Dutasteride-13C6 GG 745-¹³C₆; GI 198745-¹³C₆	Apoptosis 5 alpha Reductase	Cancer
Dutasteride- ¹³C₆ is the ¹³C labeled Dutasteride[1]. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[2].

HY-W739812

Carboxy finasteride Finasteride carboxylic acid	Others	Cancer
Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma .

HY-13613S2

Dutasteride-13C,15N,d GG 745-¹³C,¹⁵N,d; GI 198745-¹³C,¹⁵N,d	5 alpha Reductase Apoptosis Isotope-Labeled Compounds	Cancer
Dutasteride- ¹³C, ¹⁵N,d is ¹⁵N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

HY-N7510

12-O-Methylcarnosic acid 12-Methoxycarnosic acid	5 alpha Reductase	Infection Cancer
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of *5α-reductase* inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .

HY-125065

MK-4541	Androgen Receptor 5 alpha Reductase	Endocrinology Cancer
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit *5α-reductase. MK-4541 inhibits proliferation and induces apoptosis* in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	Structural Classification Monophenols Classification of Application Fields Anti-aging Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N1200

Stigmasterol glucoside	Structural Classification other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	5 alpha Reductase
Stigmasterol glucoside is a sterol isolated from P. urinaria with high antioxidant and anti-inflammatory activities , act as an inhibitor of *5α-reductase* with an IC₅₀ of 27.2 µM .

HY-B0141AR

Alpha-Estradiol (Standard) Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N7510

12-O-Methylcarnosic acid 12-Methoxycarnosic acid	Classification of Application Fields Brachyclados megalanthus Speg. Source classification Plants Infection Monophenols Chrysothamnus viscidiflorus Nutt. Terpenoids Labiatae Phenols Diterpenoids Disease Research Fields Cancer	5 alpha Reductase
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of *5α-reductase* inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .

Cat. No.	Product Name	Chemical Structure

HY-B0141AS1

Alpha-Estradiol-d2
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].

HY-13635S

Finasteride-d9
Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-B0141AS

Alpha-Estradiol-d3
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-13613S

Dutasteride-13C6
Dutasteride- ¹³C₆ is the ¹³C labeled Dutasteride[1]. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[2].

HY-13613S2

Dutasteride-13C,15N,d
Dutasteride- ¹³C, ¹⁵N,d is ¹⁵N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .

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5α-reductase

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products