12-O-Methylcarnosic acid (Synonyms: 12-Methoxycarnosic acid)

Name: 12-O-Methylcarnosic acid
Brand: MedChemExpress
SKU: HY-N7510
Rating: 4.5 (1 reviews)

Cat. No.: HY-N7510 Purity: 99.67%: FAQs
Data Sheet SDS COA Handling Instructions

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12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity.

For research use only. We do not sell to patients.

12-O-Methylcarnosic acid Chemical Structure

CAS No. : 62201-71-2

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 12-O-Methylcarnosic acid:

12-O-Methylcarnosic acid (Standard) Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	45.2 μM Compound: 2	Cytotoxicity against human AGS cells after 24 hrs by neutral red uptake assay Cytotoxicity against human AGS cells after 24 hrs by neutral red uptake assay	[PMID: 20359186]
HepG2	IC₅₀	43.5 μM Compound: 2	Cytotoxicity against human HepG2 cells after 24 hrs by neutral red uptake assay Cytotoxicity against human HepG2 cells after 24 hrs by neutral red uptake assay	[PMID: 20359186]
MRC5	IC₅₀	54.9 μM Compound: 2	Cytotoxicity against human MRC5 cells after 24 hrs by neutral red uptake assay Cytotoxicity against human MRC5 cells after 24 hrs by neutral red uptake assay	[PMID: 20359186]

In Vitro

12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%^[1].
12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

346.46

Formula

C₂₁H₃₀O₄

CAS No.

62201-71-2

Appearance

Solid

Color

White to yellow

SMILES

O=C([C@]12CCCC(C)(C)[C@]1([H])CCC3=C2C(O)=C(OC)C(C(C)C)=C3)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (144.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8863 mL	14.4317 mL	28.8634 mL
5 mM	0.5773 mL	2.8863 mL	5.7727 mL
10 mM	0.2886 mL	1.4432 mL	2.8863 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.67%

Select Batch:

Data Sheet (277 KB) SDS (537 KB)

COA (256 KB) HNMR (265 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Kazuya Murata, et al. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract. Phytother Res. 2013 Feb;27(2):212-7. [Content Brief]

[2]. Zeynep Aydogmuş, et al. Constituents of Salvia Microphylla. Nat Prod Res. 2006 Jul 10;20(8):775-81. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8863 mL	14.4317 mL	28.8634 mL	72.1584 mL
	5 mM	0.5773 mL	2.8863 mL	5.7727 mL	14.4317 mL
	10 mM	0.2886 mL	1.4432 mL	2.8863 mL	7.2158 mL
	15 mM	0.1924 mL	0.9621 mL	1.9242 mL	4.8106 mL
	20 mM	0.1443 mL	0.7216 mL	1.4432 mL	3.6079 mL
	25 mM	0.1155 mL	0.5773 mL	1.1545 mL	2.8863 mL
	30 mM	0.0962 mL	0.4811 mL	0.9621 mL	2.4053 mL
	40 mM	0.0722 mL	0.3608 mL	0.7216 mL	1.8040 mL
	50 mM	0.0577 mL	0.2886 mL	0.5773 mL	1.4432 mL
	60 mM	0.0481 mL	0.2405 mL	0.4811 mL	1.2026 mL
	80 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9020 mL
	100 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.7216 mL

12-O-Methylcarnosic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-O-Methylcarnosic acid62201-71-212-Methoxycarnosic acid5 alpha Reductase5α-reductaseInhibitorinhibitorinhibit

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12-O-Methylcarnosic acid (Synonyms: 12-Methoxycarnosic acid)

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12-O-Methylcarnosic acid Related Antibodies

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Complete Stock Solution Preparation Table

12-O-Methylcarnosic acid Related Classifications

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