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5-HT1C

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By Targets:	5-HT Receptor (26) Bacterial (4) Calcium Channel (1) Dopamine Receptor (4) Isotope-Labeled Compounds (1) Potassium Channel (2)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (23)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0115

Pizotifen 2 Publications Verification Pizotyline; BC-105	5-HT Receptor	Neurological Disease
Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B0115A

Pizotifen malate 2 Publications Verification Pizotyline malate; BC-105 malate	5-HT Receptor	Neurological Disease
Pizotifen malate (Pizotyline malate) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-14940

Volinanserin 5+ Cited Publications MDL100907; M 100907	5-HT Receptor	Neurological Disease
Volinanserin is a potent and selective antagonist of 5-HT₂ receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT₂ receptor over 5-HT_1c, alpha-1 and DA D₂ receptors. Volinanserin has antipsychotic activity.

HY-B1213

Trimipramine maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine maleate is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-100971

Spiramide AMI-193	5-HT Receptor Dopamine Receptor	Neurological Disease
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus *5-HT_1C* (K_i=4300 nM) receptors. Spiramide exhibits antipsychotic activity .

HY-123704

CGS-12066 maleate	5-HT Receptor	Neurological Disease
CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT_1A, 5-HT_1B,5-HT_1C and 5-HT_1D with pEC₅₀ values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease .

HY-B0115R

Pizotifen (Standard)	5-HT Receptor	Neurological Disease
Pizotifen (Standard) is the analytical standard of Pizotifen. This product is intended for research and analytical applications. Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B0115S

Pizotyline-d3 Pizotyline-d₃; BC-105-d₃	5-HT Receptor Isotope-Labeled Compounds	Neurological Disease
Pizotyline-d₃ is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B1213S

Trimipramine-d3 maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine-d₃ (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1][2].

HY-B1213A

Trimipramine	5-HT Receptor Bacterial	Neurological Disease
Trimipramine is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-14940A

(S)-Volinanserin (S)-MDL100907; (S)-M 100907	5-HT Receptor	Neurological Disease
(S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT₂ receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT₂ receptor over 5-HT_1c, alpha-1 and DA D₂ receptors. Volinanserin has antipsychotic activity.

HY-124117

LY 278584	5-HT Receptor	Neurological Disease
LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a K_i of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors .

HY-101208

L694247	5-HT Receptor	Neurological Disease Inflammation/Immunology
L694247 is a selective 5-HT1D agonist with the pIC₅₀ values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors , respectively .

HY-14940S

Volinanserin-d4 hydrochloride MDL100907-d₄ hydrochloride; M 100907-d₄ hydrochloride	5-HT Receptor	Neurological Disease
Volinanserin-d₄ (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].

HY-B1213R

Trimipramine maleate (Standard)	5-HT Receptor Bacterial	Neurological Disease
Trimipramine (maleate) (Standard) is the analytical standard of Trimipramine (maleate). This product is intended for research and analytical applications. Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-103151

CP94253 hydrochloride	5-HT Receptor	Neurological Disease
CP94253 hydrochloride is a potent and selective agonist of 5-HT_1B receptor (K_i= 2 nM in a radioligand binding assay).K_i values for 5-HT_1A, 5-HT_1D, 5-HT_1C and 5-HT₂ receptors are 89, 49, 860, and 1600 nM respectively . CP94253 hydrochloride is centrally active upon systemic administration in vivo .

HY-106904

Nexopamil	Calcium Channel 5-HT Receptor Dopamine Receptor	Cardiovascular Disease
Nexopamil is a calcium antagonist of Ca ²⁺ channel, 5HT₂, 5HT_1A, *5HT_1C* and dopamine D₂ receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease .

HY-19545A

SCH-23390 hydrochloride Maximum Cited Publications 22 Publications Verification R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM .

HY-108400

SCH-23390 maleate R-(+)-SCH-23390 maleate	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM .

HY-103151A

CP94253	5-HT Receptor	Others
CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. CP94253 binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, with K_is of 2, 89, 49, 860 and 1600 nM. CP94253 causes satiety, anorexia, weight loss and hyperlocomotion in rats model .

HY-101009

Methiothepin maleate Metitepine maleate; Ro-8-6837 maleate	5-HT Receptor	Neurological Disease
Methiothepin maleate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-111491

Methiothepin Metitepine; Ro 8-6837	5-HT Receptor	Neurological Disease
Methiothepin is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-107836

Methiothepin mesylate Metitepine mesylate; Ro 8-6837 mesylate	5-HT Receptor	Neurological Disease
Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-101324

MK-212 CPP	5-HT Receptor	Neurological Disease
MK-212 (CPP) is a centrally acting *5-HT_1C/5-HT₂* agonist. MK-212 can stimulate phosphoinositide hydrolysis in cerebral cortex .

HY-101324A

MK-212 monohydrochloride CPP monohydrochloride	5-HT Receptor	Neurological Disease
MK-212 (CPP) monohydrochloride is a centrally acting *5-HT_1C/5-HT₂* agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex .

HY-106805

ICI 169369	5-HT Receptor	Others
ICI 169369 is an orally active, specific serotonin and 5-HT₂/5-HT_1C receptor competitive antagonist. ICI 169369 exhibits K_i values of 1.79 x 10 ⁻⁸ and 1.58 x 10 ⁻⁶ M for 5-HT₂ and 5-HT₁, respectively .

Spiramide AMI-193	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Source classification Rosaceae Spiraea japonica Plants Disease Research Fields	5-HT Receptor Dopamine Receptor
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus *5-HT_1C* (K_i=4300 nM) receptors. Spiramide exhibits antipsychotic activity .

Cat. No.	Product Name	Chemical Structure

HY-B0115S

Pizotyline-d3
Pizotyline-d₃ is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B1213S

Trimipramine-d3 maleate
Trimipramine-d₃ (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1][2].

HY-14940S

Volinanserin-d4 hydrochloride
Volinanserin-d₄ (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83619

	HTR2C Antibody (YA3364) 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5HT1C; 5HT2C; 5HTR2C; 5Hydroxytryptamine 2C receptor; HTr1C; HTR2C	WB	Human, Mouse, Rat
	HTR2C Antibody (YA3364) is a biotin-conjugated non-conjugated IgG antibody, targeting HTR2C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). HTR2C Antibody (YA3364) can be used for WB experiment in human, mouse, rat background.

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5-HT1C

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products