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8-Oxoguanine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (1) Endogenous Metabolite (2) Glycosyltransferase (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

8-Hydroxyguanine 8-Oxoguanine; 8-oxo-Gua	Endogenous Metabolite	Metabolic Disease
8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage .

SU0268 1 Publications Verification	Glycosyltransferase	Infection Inflammation/Immunology Cancer
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .

OGG1-IN-08 1 Publications Verification	Others	Inflammation/Immunology
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC₅₀ value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .

TH5487 Maximum Cited Publications 8 Publications Verification	DNA/RNA Synthesis	Inflammation/Immunology
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC₅₀ of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes .

8-Hydroxyguanine hydrochloride 8-Oxoguanine hydrochloride; 8-oxo-Gua hydrochloride	Endogenous Metabolite	Metabolic Disease
8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage .

Species:	Human (3) E.coli (1)
Tag:	His (3) SUMO (1) Tag Free (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

	OGG1 Protein, Human (His) 8-Oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (His) is the recombinant human-derived OGG1 protein, expressed by E. coli , with C-6*His labeled tag.

	OGG1 Protein, Human (N-His) 8-Oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity.It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY).OGG1 Protein, Human (N-His) is the recombinant human-derived OGG1 protein, expressed by E.coli , with N-6*His labeled tag.

	OGG1 Protein, Human N-Glycosylase/DNA Lyase; 8-Oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (GST) is the recombinant human-derived OGG1 protein, expressed by E. coli , with tag free.

	MutT Protein, E.coli (His-SUMO) mutT; b0099; JW0097; 8-oxo-dGTP diphosphatase; 8-oxo-dGTPase; EC 3.6.1.55; 7,8-dihydro-8-Oxoguanine-triphosphatase; Mutator protein MutT; dGTP pyrophosphohydrolase	E.coli	E. coli
	The MutT protein maintains the genome by hydrolyzing 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to their corresponding monophosphates. Integrity plays a key role. This prevents misincorporation of 8-oxoGua into DNA and RNA, ensuring the fidelity of the nucleotide library. MutT Protein, E.coli (His-SUMO) is the recombinant E. coli-derived MutT protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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