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ATG5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Atg7 (4) Atg8/LC3 (3) Autophagy (7) Bacterial (1) Cytochrome P450 (1) Endogenous Metabolite (1) HBV (1) P-glycoprotein (1) p62 (2) PI3K (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Fillers (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W018791

Bifendate 1 Publications Verification DDB	HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein	Infection Cardiovascular Disease Cancer
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) ^[5] .

HY-N0538

Xylitol Xylite	Autophagy Endogenous Metabolite Bacterial Atg7 Atg8/LC3	Metabolic Disease Cancer
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and *Atg5-Atg12* upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

HY-RS01152

ATG5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATG5 Human Pre-designed siRNA Set A contains three designed siRNAs for ATG5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATG5 Human Pre-designed siRNA Set A ATG5 Human Pre-designed siRNA Set A

HY-RS17532

Atg5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Atg5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atg5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atg5 Mouse Pre-designed siRNA Set A Atg5 Mouse Pre-designed siRNA Set A

HY-151914

Antitumor agent-82	Atg7 Autophagy	Cancer
Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway .

HY-173133

Antitumor agent-199	Autophagy Atg7	Cancer
Antitumor agent-199 (Compound 4b) is an antitumor agent. Antitumor agent-199 exhibits significant antiproliferative activity against multiple tumor cell lines. Antitumor agent-199 can induce autophagy in cancer cells via the ATG5/ATG7 pathway and can be used in the study of cancer .

HY-170594

Antitumor agent-192	Atg7 Autophagy	Cancer
Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the *ATG5/ATG7* pathway. Antitumor agent-192 has an IC₅₀ of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts ^[1].

HY-167843

Alborixin	Akt PI3K Autophagy	Neurological Disease
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, *ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β*-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease .

HY-157548

Antitumor agent-133	p62 Atg8/LC3 Autophagy	Cancer
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC₅₀=17.13 μM) and Huh7 (IC₅₀=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0538

Xylitol Xylite	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Autophagy Endogenous Metabolite Bacterial Atg7 Atg8/LC3
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and *Atg5-Atg12* upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

HY-167843

Alborixin	Structural Classification Microorganisms Antibiotics Source classification	Akt PI3K Autophagy
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, *ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β*-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease .

Cat. No.	Compare	Product Name	Species	Source

HY-P7620

	ATG5 Protein, Human rHuATG5; Autophagy protein 5; APG5-like; Apoptosis-specific protein; APG5L; ASP; ATG5;	Human	E. coli
	ATG5 is an important participant in the formation of autophagy vesicles and binds to ATG12 through a ubiquitin-like system, which is critical for the lipidation of ATG8 family proteins. It plays a crucial role in mitochondrial quality control, affects cell longevity, and is critical for lymphocyte development, antigen processing, axonal morphology maintenance, adipocyte differentiation, primary ciliogenesis, and apoptotic processes. ATG5 Protein, Human is the recombinant human-derived ATG5 protein, expressed by E. coli , with tag free. The total length of ATG5 Protein, Human is 275 a.a., with molecular weight of ~33.0 kDa.

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HY-P80022

	ATG5 Antibody APG 5 antibody; APG 5L antibody; APG5 antibody; APG5 autophagy 5 like antibody; APG5 like antibody; APG5-like antibody; APG5L antibody; Apoptosis specific protein antibody; Apoptosis-specific protein antibody; ASP antibody; ATG 5 antibody; ATG5 antibody; ATG5 autophagy related 5 homolog antibody; ATG5_HUMAN antibody; Autophagy protein 5 antibody; Autophagy related 5 antibody; hAPG5 antibody; Homolog of S Cerevisiae autophagy 5 antibody; OTTHUMP00000040507 antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Rat, Mouse, Monkey
	ATG5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to ATG5. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Rat, Mouse, Monkey.

HY-P80545

	APG5L Antibody APG 5L; APG5; APG5 autophagy 5 like; APG5 like; APG5-like; Apoptosis specific protein; ASP; ATG 5; ATG5 autophagy related 5 homolog; Autophagy protein 5; hAPG5	WB, ICC/IF, IP	Human, Mouse, Rat
	APG5L Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to APG5L. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-N0538

Xylitol Xylite		Fillers
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and *Atg5-Atg12* upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

HY-RS01152

ATG5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATG5 Human Pre-designed siRNA Set A contains three designed siRNAs for ATG5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17532

Atg5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Atg5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atg5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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ATG5

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Recombinant Proteins

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