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BCL2-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (22) Apoptosis (8) Autophagy (5) Caspase (1) CDK (1) EGFR (1) ERK (1) Fungal (1) HDAC (1) JNK (1) Ligands for E3 Ligase (1) Parasite (2) PARP (1) Phosphatase (1) PROTACs (1) ROS Kinase (1) Small Interfering RNA (siRNA) (6) VD/VDR (1)
By Research Areas:	Cancer (24) Infection (3) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (6) siRNAs (6)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Targets Recommended: Bcl-2 Family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129681

MCL-1/BCL-2-IN-1	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

HY-135273

A-1211212 BCL2-IN-1	Bcl-2 Family	Cancer
A-1211212 (BCL2-IN-1) is a potent *Bcl-2* inhibitor. BCL2-IN-1 binds Bcl-2 with a K_i of <0.01 nM .

HY-156877

Bcl-2-IN-16	Others	Cancer
Bcl-2-IN-16 is a Bcl-2 inhibitor .

HY-149436

CDK2/Bcl2-IN-1	CDK	Cancer
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

HY-144430

Bcl-2/Mcl-1-IN-1	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-1 (compound 3) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 1.19 μM and 4.53 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-1 can be used for the research of cancer .***

HY-144431

Bcl-2/Mcl-1-IN-3	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-3 (compound 1) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.14 μM and 0.23 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer .***

HY-144428

Bcl-2/Mcl-1-IN-2	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-2 (compound 2) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.88 μM and 4.70 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer .***

HY-159513

Bcl-2/Mcl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting *Bcl-2* (K_i=0.49 μM) and Mcl-1 (K_i=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research .

HY-RS01418

BCL2A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2A1 Human Pre-designed siRNA Set A BCL2A1 Human Pre-designed siRNA Set A

HY-RS01419

Bcl2a1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1 Rat Pre-designed siRNA Set A Bcl2a1 Rat Pre-designed siRNA Set A

HY-RS01420

Bcl2a1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2a1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1a Mouse Pre-designed siRNA Set A Bcl2a1a Mouse Pre-designed siRNA Set A

HY-RS01421

BCL2L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L1 Human Pre-designed siRNA Set A BCL2L1 Human Pre-designed siRNA Set A

HY-RS01422

Bcl2l1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Mouse Pre-designed siRNA Set A Bcl2l1 Mouse Pre-designed siRNA Set A

HY-RS01423

Bcl2l1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Rat Pre-designed siRNA Set A Bcl2l1 Rat Pre-designed siRNA Set A

HY-161415

BCL-xL/BCL-2 ligand 1	Ligands for E3 Ligase	Cancer
BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and *BCL-2* protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410) .

HY-N8579

Eugenyl benzoate	Others	Inflammation/Immunology
Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of BCL-2 inhibitors .

HY-N3828

epi-Eriocalyxin A	Apoptosis ERK JNK	Cancer
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits ERK1/2 and JNK activation, which suppresses Bcl-2 expression .

HY-118925

Holothurin A	Bcl-2 Family HDAC Phosphatase	Cancer
Holothurin A is a potent inhibitor against *BCL2, HDAC1* and PTPN2 with an anticancer activity, which is derived from sea cucumber Holothuria scabra. Holothurin A plays an essential role in the process of apoptosis, cell cycle and suppressing tumor .

HY-15464

(R)-(-)-Gossypol 5+ Cited Publications AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-15464A

(R)-(-)-Gossypol acetic acid 5+ Cited Publications AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-114310

VDR agonist 1	VD/VDR Apoptosis	Cancer
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC₅₀ of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .

HY-19551

Apogossypolone ApoG2	Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase	Infection Cancer
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with K_i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X_L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy . Apogossypolone also has antifungal activity .

HY-10969

Obatoclax Mesylate Maximum Cited Publications 10 Publications Verification GX15-070 Mesylate	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .

HY-10969A

Obatoclax GX15-070	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .

HY-N10481

Aviculin	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio .

HY-169083

Bcl-2-IN-22	Apoptosis Bcl-2 Family	Cancer
Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC₅₀ value of 0.014 μM. In addition, Bcl-2-IN-22 targets *BCL-2* family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress *BCL?2* .

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent .

HY-125876

PROTAC Bcl2 degrader-1	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of *Bcl-2* (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

HY-147826

EGFR-IN-60	EGFR Apoptosis	Cancer
EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFR ^WT, EGFR ^T790M, EGFR ^L858R and JAK3 with IC₅₀s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFR ^T790M mutation (IC₅₀=1.32 µM) over A431 cells overexpressing EGFR ^WT (IC₅₀=4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio .

HY-15191B

(S)-Sabutoclax (S)-BI-97C1	Bcl-2 Family	Cancer
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .

HY-123715

Anticancer agent 255	Others	Cancer
Anticancer agent 255 is a monocarbonylated curcumin-1,2,3-oxazole conjugate with significant anticancer activity. The IC₅₀ values of Anticancer agent 255 in prostate cancer cells PC-3 and DU-145 are 8.8μM and 9.5μM respectively. The IC₅₀ values of Anticancer agent 255 against breast cancer cells MCF-7, MDA-MB-231 and 4T1 are 6μM, 10μM and 6.4μM, showing good anti-cancer activity Effect. Anticancer agent 255 can induce mitochondria-mediated apoptosis in cancer cells and prevent cell cycle progression. Anticancer agent 255 down-regulated the cell proliferation marker PCNA and inhibited the activation of cell survival proteins. Anticancer agent 255 up-regulated the pro-apoptotic protein Bax and down-regulated the anti-apoptotic protein Bcl-2 .

(R)-(-)-Gossypol 5+ Cited Publications AT-101; R-(-)-gossypol acetic acid	Malvaceae Structural Classification Classification of Application Fields Gossypium Source classification Phenols Plants Disease Research Fields Cancer	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

CDK2/Bcl2-IN-1	Structural Classification Terpenoids Zygophyllaceae Source classification Diterpenoids Plants Zygophyllum album L.f.	CDK
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

Eugenyl benzoate	Structural Classification Microorganisms Simple Phenylpropanols Source classification Phenylpropanoids	Others
Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of BCL-2 inhibitors .

epi-Eriocalyxin A	Other Terpenoids Structural Classification Lychnophora antillana Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields Cancer	Apoptosis ERK JNK
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits ERK1/2 and JNK activation, which suppresses Bcl-2 expression .

Holothurin A	Structural Classification Terpenoids Pentacyclic Triterpenoids	Bcl-2 Family HDAC Phosphatase
Holothurin A is a potent inhibitor against *BCL2, HDAC1* and PTPN2 with an anticancer activity, which is derived from sea cucumber Holothuria scabra. Holothurin A plays an essential role in the process of apoptosis, cell cycle and suppressing tumor .

Aviculin	Classification of Application Fields Polygonum aviculare L. Polygonaceae Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Bcl-2 Family
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio .

BCL2A1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
BCL2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bcl2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1a Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bcl2a1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
BCL2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bcl2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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