BTLA

By Targets:	Apoptosis (2) CD28 (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (5)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99961

Tifcemalimab JS004	CD28	Cancer
Tifcemalimab (JS004) is a humanized anti-BTLA (B and T lymphocyte attenuation factor) monoclonal antibody. Tifcemalimab blocks the interaction of HVEM-BTLA by binding to BTLA, and thus blocks the inhibitory signaling pathway mediated by BTLA. Tifcemalimab can be used in research of cancer .

HY-P990773

Venanprubart	CD28	Inflammation/Immunology
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-RS01669

BTLA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BTLA Human Pre-designed siRNA Set A contains three designed siRNAs for BTLA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BTLA Human Pre-designed siRNA Set A BTLA Human Pre-designed siRNA Set A

HY-159885

MG-B-28	Apoptosis	Cancer
MG-B-28 is an inhibitor of *BTLA-HVEM* with an IC₅₀ value of 906 nM. MG-B-28 promotes T-cell activation in a dose-dependent manner by blocking the *BTLA-HVEM* interaction .

HY-P10851

HVEM(14-39)	Apoptosis	Inflammation/Immunology Cancer
HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with *BTLA* with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of *BTLA* and HVEM in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer .

HY-P991038

Zadoprubart	CD28	Inflammation/Immunology
HY-P991038 is an *BTLA*-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Cat. No.	Product Name	Target	Research Area

HY-P10851

HVEM(14-39)	Apoptosis	Inflammation/Immunology Cancer
HVEM(14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with *BTLA* with a K_D of 0.102 μM. HVEM(14-39) enhances the activation and proliferation of T cells by regulating the expression of *BTLA* and HVEM in T cells, and promotes the transformation of cells into effector memory T cells. HVEM(14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM(14-39) has immunomodulatory effects and can be used in the study of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P99961

Tifcemalimab JS004	CD28	Cancer
Tifcemalimab (JS004) is a humanized anti-BTLA (B and T lymphocyte attenuation factor) monoclonal antibody. Tifcemalimab blocks the interaction of HVEM-BTLA by binding to BTLA, and thus blocks the inhibitory signaling pathway mediated by BTLA. Tifcemalimab can be used in research of cancer .

HY-P990298

*Anti-Mouse BTLA/CD272 Antibody (6A6)*	Inhibitory Antibodies	Others
Anti-Mouse BTLA/CD272 Antibody (6A6) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse BTLA/CD272.

HY-P990773

Venanprubart	CD28	Inflammation/Immunology
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-108813

Belatacept BMS 224818; LEA 29Y	Inhibitory Antibodies	Inflammation/Immunology
Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation .

HY-P991038

Zadoprubart	CD28	Inflammation/Immunology
HY-P991038 is an *BTLA*-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990600

Icatolimab	Inhibitory Antibodies	Inflammation/Immunology
Icatolimab is a CHO-expressed humanized antibody targeting *BTLA/CD272*. Icatolimab contains huIgG4SP type heavy chains and huκ type light chains, with a predicted molecular weight (MW) of 146 kDa. The isotype control for Icatolimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).

Recombinant Proteins Recommended:

BTLA

Species:	Human (5) Rhesus Macaque (2) Rat (1) Mouse (2) Cynomolgus (1)
Tag:	His (6) Avi (2) Myc (1) Fc (5)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P7678

	BTLA/CD272 Protein, Human (HEK293, His) rHuBTLA/CD272, His; B- and T-Lymphocyte Attenuator; CD272; BTLA	Human	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, His) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75466

	BTLA/CD272 Protein, Rat (HEK293, mFc) B- and T-lymphocyte attenuator; CD272; BTLA	Rat	HEK293
	BTLA/CD272 protein inhibits antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. It regulates immune responses through cis and trans interactions with TNFRSF14. In cis, it maintains resting state in naive T cells, while in trans, it supports survival signals in effector T cells. BTLA/CD272 interacts with PTPN6/SHP-1, PTPN11/SHP-2, and TNFRSF14/HVEM. BTLA/CD272 Protein, Rat (HEK293, mFc) is the recombinant rat-derived BTLA/CD272 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of BTLA/CD272 Protein, Rat (HEK293, mFc) is 154 a.a., with molecular weight of ~55-77 kDa.

HY-P78078

	BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) CD272; BTLA; BTLA1; FLJ16065; MGC129743	Human	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P7679

	BTLA/CD272 Protein, Human (HEK293, Fc) rHuBTLA/CD272, C-Fc; B- and T-Lymphocyte Attenuator; CD272; BTLA	Human	HEK293
	BTLA/CD272 Protein, Human (HEK293, Fc) is a recombinant human BTLA/CD272 produced in HEK293 cells, with an Fc fragment at the C-terminus. BTLA/CD272 is a suppressor molecule belonging to the immunoglobulin superfamily which is involved in the inhibition of immune responses.

HY-P75467

	BTLA/CD272 Protein, Mouse (HEK293, hFc) B- and T-lymphocyte attenuator; CD272; BTLA	Mouse	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Mouse (HEK293, hFc) is 147 a.a., with molecular weight of 57-62 kDa.

HY-P76751

	BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc) B- and T-lymphocyte attenuator; CD272; BTLA	Rhesus Macaque	HEK293
	BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc) is 125 a.a., with molecular weight of ~41.4 KDa.

HY-P76752

	BTLA/CD272 Protein, Rhesus Macaque (HEK293, His) B- and T-lymphocyte attenuator; CD272; BTLA	Rhesus Macaque	HEK293
	BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived BTLA/CD272 protein, expressed by HEK293 , with C-His labeled tag. The total length of BTLA/CD272 Protein, Rhesus Macaque (HEK293, His) is 125 a.a., with molecular weight of ~19.3 KDa.

HY-P78246

	BTLA/CD272 Protein, Mouse (HEK293, His) CD272; BTLA; BTLA1; FLJ16065; MGC129743	Mouse	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BTLA/CD272 protein, expressed by HEK293 , with C-His labeled tag. The total length of BTLA/CD272 Protein, Mouse (HEK293, His) is 147 a.a., with molecular weight of 35-50 kDa.

HY-P78394

	BTLA/CD272 Protein, Human (HEK293, His-Avi) CD272; BTLA; BTLA1; FLJ16065; MGC129743	Human	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, His-Avi) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P703766

	BTLA Protein, Cynomolgus (HEK293, His)	Cynomolgus	HEK293

HY-P72030

	BTLA/CD272 Protein, Human (HEK293, hFc-Myc) B- and T-lymphocyte-associated protein; CD272;	Human	HEK293
	The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, hFc-Myc) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc, C-Myc labeled tag.

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HY-P81619

	BTLA Antibody (YA1364) BTLA; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD antigen CD272	FC, ELISA	Human
	BTLA Antibody (YA1364) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1364), targeting BTLA. BTLA Antibody (YA1364) can be used for FC, ELISA experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS01669

BTLA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BTLA Human Pre-designed siRNA Set A contains three designed siRNAs for BTLA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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