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Results for "

CBR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Antibiotic (1) Apoptosis (5) Autophagy (2) Bacterial (3) Cannabinoid Receptor (2) CCR (1) COX (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) Ferroptosis (1) Glutathione Peroxidase (1) HIF/HIF Prolyl-Hydroxylase (1) Keap1-Nrf2 (2) NF-κB (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) PROTACs (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100012

CBR-5884 Maximum Cited Publications 17 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .

HY-134001

CBR-470-2	Keap1-Nrf2	Metabolic Disease
CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis .

HY-134205A

CBR-470-1 1 Publications Verification	Keap1-Nrf2	Neurological Disease Metabolic Disease
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP ⁺-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .

HY-151105

CBR Agonist-1	Cannabinoid Receptor	Neurological Disease
CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the K_i values of 0.18 μM for CB₁R and 1.22 μM for CB₂R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases .

HY-157451

CBR1-IN-7	Others	Cancer
CBR1-IN-7 (Compound JV-2) is a human *CBR1* inhibitor (IC₅₀=8 μM). CBR1-IN-7 can be used in cancer research .

HY-157447

CBR1-IN-4	Others	Cancer
CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC₅₀=0.09 μM). CBR1-IN-4 can be used in cancer research .

HY-157448

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a *CBR1* inhibitor with chemosensitizing and cardioprotective activities .

HY-157449

CBR1-IN-5	Others	Cancer
CBR1-IN-5 (compound 13o) is a potent inhibitor of *CBR1* with an IC₅₀ of 0.1 μM .

HY-145985

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

HY-145986

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

HY-157445

CBR1-IN-3	Others	Metabolic Disease
CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM .

HY-151107

CBR Agonist-2	Cannabinoid Receptor	Neurological Disease
CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC₅₀ and a K_i of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system .

HY-135184

Rifaquizinone CBR-2092; TNP-2092	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Rifaquizinone (CBR-2092) is a Rifamycin-Quinolone Hybrid Antibiotic. Rifaquizinone inhibits wild-type S. aureus RNA polymerase with an IC₅₀ of 34 nM. Rifaquizinone is effective against S. aureus infections, with MICs ranged from 0.008 to 0.5 μg/mL for 300 clinical isolates of staphylococci and streptococci .

HY-RS02004

CBR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR1 Human Pre-designed siRNA Set A CBR1 Human Pre-designed siRNA Set A

HY-RS02005

CBR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR3 Human Pre-designed siRNA Set A CBR3 Human Pre-designed siRNA Set A

HY-RS02006

CBR4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBR4 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR4 Human Pre-designed siRNA Set A CBR4 Human Pre-designed siRNA Set A

HY-121710

MonoHER 7-Monohydroxyethylrutoside	Others	Cardiovascular Disease
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .

HY-161974

Adamantan-C-amide-PEG2-C-Br	Others	Cancer
Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972) .

HY-157450

YF-Mo1	Apoptosis	Cancer
YF-Mo1 (compound 9) is a *CBR1* inhibitor with an IC₅₀ value of 1.1 μM .

HY-13930

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

HY-157452

(8S)-Methyl zearalenone	Others	Cancer
(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC₅₀ of 0.21 μM .

HY-155587

Hydroxy-PP	Others	Cancer
Hydroxy-PP is a potent CBR1 inhibitor with an IC₅₀ value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC₅₀ value of 5 nM .

HY-13930R

Miquelianin (Standard)	Endogenous Metabolite	Cancer
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

HY-156694

Hydroxy-PP-Me	Apoptosis	Cancer
Hydroxy-PP-Me is a potent and specific *CBR1* inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As₂O₃-induced apoptotic cell death compared with As₂O₃ alone .

HY-157444

5,3',4',3'',4'',5''-6-O-Ethyl-EGCG	HIF/HIF Prolyl-Hydroxylase	Cancer
5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) is a potent adjuvant obtained by optimization of the structure of EGCG. 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) decreases the expression of HIF-1α and *CBR1* at both the mRNA and protein levels .

HY-N0148

Rutin 10+ Cited Publications Rutoside; Quercetin 3-O-rutinoside	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N0148R

Rutin (Standard)	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-161972

ZX782	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination . ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Flavonols Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Endogenous Metabolite
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

Rutin Maximum Cited Publications 11 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

Rutin (Standard)	Flavonols Structural Classification Flavonoids other families Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Miquelianin (Standard)	Flavonols Structural Classification Flavonoids Microorganisms other families Source classification Phenols Polyphenols Plants Endogenous metabolite	Endogenous Metabolite
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (1) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75605

	CBR3 Protein, Human (His) Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; CBR3	Human	E. coli
	The CBR3 protein uses NADPH to convert carbonyl compounds into alcohols. CBR3 Protein, Human (His) is the recombinant human-derived CBR3 protein, expressed by E. coli , with N-His labeled tag. The total length of CBR3 Protein, Human (His) is 277 a.a., with molecular weight of ~37 kDa.

HY-P72272

	CBR1 Protein, Human (P.pastoris, His) Carbonyl Reductase 1; SDR21C1	Human	P. pastoris
	CBR1 is an NADPH-dependent reductase with broad substrate specificity and plays a key role in the reduction of various carbonyl compounds, including quinones, prostaglandins, menadione, and xenobiotics. Crucially, CBR1 converts the anthracyclines doxorubicin and daunorubicin into their cardiotoxic forms doxorubicin and daunorubicin. CBR1 Protein, Human (P.pastoris, His) is the recombinant human-derived CBR1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CBR1 Protein, Human (P.pastoris, His) is 276 a.a., with molecular weight of ~33.0 kDa.

HY-P700408

	CNR1 Protein-VLP, Human (HEK293, His) cannabinoid receptor 1 (brain); CNR; cannabinoid receptor 1; CANN6; CB R; CB1; CB1A; CB1K5; central cannabinoid receptor; CB-R; CB1R	Human	HEK293
	CNR1 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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HY-P81627

	CB1 Antibody CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Rat
	CB1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CB1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). CB1 Antibody can be used for WB, IHC-P, IHC-F, ICC/IF, ELISA experiments in human, rat backgrounds.

HY-P82605

	Phospho-Cannabinoid Receptor I (Ser316) Antibody (YA2350) CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6	WB	Human
	Phospho-Cannabinoid Receptor I (Ser316) Antibody (YA2350) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-Cannabinoid Receptor I (Ser316), with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). Phospho-Cannabinoid Receptor I (Ser316) Antibody (YA2350) can be used for WB experiment in human background.

HY-P80590

	CBR1 Antibody (YA810) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreduc	WB, ICC/IF	Human
	CBR1 Antibody (YA810) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to CBR1 (2C9). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P82650

	CBR3 Antibody (YA2395) CBR3; Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3	WB	Human
	CBR3 Antibody (YA2395) is a biotin-conjugated non-conjugated IgG antibody, targeting CBR3, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). CBR3 Antibody (YA2395) can be used for WB experiment in human background.

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