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CHS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (2) Biochemical Assay Reagents (1) Caspase (2) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) Fungal (8) Glucocorticoid Receptor (1) NAMPT (1) Necroptosis (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (2) Topoisomerase (1) TRP Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (5)
Oligonucleotides:	siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10079

CHS-828 GMX1778	NAMPT Apoptosis	Cancer
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC₅₀ less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-13706A

CAY10471 TM30089	Prostaglandin Receptor	Inflammation/Immunology
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model .

HY-116730

CHS-111	Reactive Oxygen Species	Others
CHS-111 is a benzyl indazole inhibitor of superoxide anion O ^2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC₅₀ of 3.9 μM .

HY-W010800A

Cholesterol hemisuccinate Tris salt Cholesterol hydrogen succinate Tris salt; CHS-Tris	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesterol hemisuccinate Tris salt (CHS-Tris) is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology. CHS-Tris and Lauryl Maltose Neopentyl Glycol (LMNG) or n-Dodecyl-β-D-Maltoside (DDM) are used together for the solubilization of membrane proteins while maintaining structural integrity and activity. Cholesteryl succinate also reportedly exhibits antiproliferative activity.

HY-151419

Chitin synthase inhibitor 9	Fungal	Infection
Chitin synthase inhibitor 9 is a *chitin synthase (CHS)* inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .

HY-151418

Chitin synthase inhibitor 8	Fungal	Infection
Chitin synthase inhibitor 8 is a *chitin synthase (CHS)* inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .

HY-149585

Chitin synthase inhibitor 14	Fungal	Infection
Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants .

HY-144391

Chitin synthase inhibitor 1	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC₅₀=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants .

HY-151417

Chitin synthase inhibitor 7	Fungal	Infection
Chitin synthase inhibitor 7 (compound 9c) is a potent *chitin synthase (CHS)* inhibitor with an IC₅₀ value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .

HY-151416

Chitin synthase inhibitor 6	Fungal	Infection
Chitin synthase inhibitor 6 (compound 9b) is a potent *chitin synthase (CHS)* inhibitor with an IC₅₀ value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Fungal	Infection
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

HY-163673

Glucocorticoid receptor modulator 4	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor modulator 4 (Compound DL5) is a conjugate of a linker and a glucocorticoid receptor modulator. Glucocorticoid receptor modulator 4 exhibits GRE Reporter activity in mTNF expressing K562 cell with an EC₅₀ of 40 μM. Glucocorticoid receptor modulator 4 binds with an anti-tumor necrosis factor (TNF) antibody, and exhibits anti-inflammtory activity against arthritis in mouse models .

HY-150583

Chitin synthase inhibitor 2	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC₅₀ value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .

HY-158820

Cosdosiran QPI-1007	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-E70364

IgdE protease	Biochemical Assay Reagents	Inflammation/Immunology
IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .

HY-134098

Diisopropyl adipate Adipic acid diisopropyl ester	TRP Channel	Others
Diisopropyl adipate is an alternative plasticizer and a TRPA1 activator. Diisopropyl adipate activates TRPA1 and enhances FITC-induced contact hypersensitivity (CHS).Diisopropyl adipate also serves as an ingredient in cosmetics and drug formulations topically applied to the skin. Diisopropyl adipate can be used as an excipient, such as emollients, plasticizers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

Cat. No.	Product Name	Type

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Cell Assay Reagents
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

Cat. No.	Compare	Product Name	Species	Source

HY-P79244

	Chondroitinase ABC Protein, P. vulgaris (His) Chondroitin sulfate ABC endolyase; Chondroitin ABC endoeliminase; Chondroitin ABC lyase I; Chondroitin sulfate ABC lyase I; CHS ABC lyase I; Chondroitinase ABC I; cABC I; Endochondroitinase ABC; INN: Condoliase	Others	E. coli
	Chondroitinase ABC protein is an endolytic glycosaminoglycan lyase with broad specificity that effectively degrades polysaccharides such as chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate, and smaller degree of hyaluronic acid. This enzyme activity is facilitated by β-elimination of the 1,4-hexosamine bond, resulting in unsaturated tetra- and disaccharides. Chondroitinase ABC Protein, P. vulgaris (His) is the recombinant Chondroitinase ABC protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of Chondroitinase ABC Protein, P. vulgaris (His) is 997 a.a., with molecular weight of ~110 kDa.

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Cat. No.	Product Name		Classification

HY-158820

Cosdosiran QPI-1007		siRNAs
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium		siRNAs
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

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